| Weight | 174.087 g/mol |
|---|---|
| Formula | C5H3FN2O4 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 1 |
5-Fluoroorotic acid (703-95-7)
fluoroorotic acid
Score:
#622 in Microbiology
,
#5060 in Biology
,
#6540 in Chemistry
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- 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. (Methods in Enzymology, 1987)
- Studies on Fluorinated Pyrimidines: III. The Metabolism of 5-Fluorouracil-2-C14 and 5-Fluoroorotic-2-C14 Acid in Vivo (Cancer Research, 1958)
- Selection of ura5 and ura3 mutants from the two varieties of Cryptococcus neoformans on 5-fluoroorotic acid medium. (Medical Mycology, 1992)
- Inhibition of Ribosomal Ribonucleic Acid Maturation in Rat Liver by 5-Fluoroorotic Acid Resulting in the Selective Labeling of Cytoplasmic Messenger Ribonucleic Acid (Journal of Biological Chemistry, 1971)
- Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro. (Antimicrobial Agents and Chemotherapy, 1989)
- Positive selection for Dictyostelium discoideum mutants lacking UMP synthase activity based on resistance to 5-fluoroorotic acid (Molecular Genetics and Genomics, 1991)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - fluoroorotic acid
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SMILESC1(=C(NC(=O)NC1=O)C(=O)O)F
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InChIKeySEHFUALWMUWDKS-UHFFFAOYSA-N
- Pubchem - 5-Fluoroorotic acid
- Wikipedia - 5-fluoroorotic acid
5-Fluoroorotic acid (5FOA) is a fluorinated derivative of the pyrimidine precursor orotic acid. It is used in yeast genetics to select for the absence of the URA3 gene, which encodes the enzyme for the decarboxylation of 5-fluoroorotic acid to 5-fluorouracil, a toxic metabolite.
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