| Weight | 163.136 g/mol |
|---|---|
| Formula | C7H5N3O2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 1 |
7-nitroindazole (2942-42-9)
7-nitro-indazole
Score:
#837 in Neuroscience
,
#3681 in Biology
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- Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects. (British Journal of Pharmacology, 1993)
- 7Nitro indazole, an inhibitor of nitric oxide synthase, exhibits antinociceptive activity in the mouse without increasing blood pressure (British Journal of Pharmacology, 1993)
- Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. (Journal of Neurochemistry, 2002)
- Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles (British Journal of Pharmacology, 1993)
- The NOS Inhibitor, 7-Nitroindazole, Decreases Focal Infarct Volume but Not the Response to Topical Acetylcholine in Pial Vessels (Journal of Cerebral Blood Flow and Metabolism, 1994)
- The Neuronal Nitric Oxide Synthase Inhibitor, 7Nitroindazole, Protects Against MethamphetamineInduced Neurotoxicity In Vivo (Journal of Neurochemistry, 2002)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - 7-nitro-indazole
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SMILESC1=CC2=C(C(=C1)[N+](=O)[O-])NN=C2
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InChIKeyPQCAUHUKTBHUSA-UHFFFAOYSA-N
- Pubchem - 7-nitroindazole
- Wikipedia - 7-nitroindazole
7-Nitroindazole, or 7-NI, is a heterocyclic small molecule containing an indazole ring that has been nitrated at the 7 position. Nitroindazole acts as a selective inhibitor for neuronal nitric oxide synthase, a hemoprotein enzyme that, in neuronal tissue, converts arginine to citrulline and nitric oxide (NO). Nitric oxide can diffuse through the plasma membrane into neighbouring cells, allowing cell signalling, so nitroindazole indirectly inhibits this signalling process.
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