| Weight | 243.306 g/mol |
|---|---|
| Formula | C15H17NO2 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 4 |
Agomelatine (138112-76-2)
Score:
#604 in Neuroscience
,
#2712 in Biology
,
#3390 in Chemistry
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- The Novel Melatonin Agonist Agomelatine (S20098) Is an Antagonist at 5-Hydroxytryptamine2C Receptors, Blockade of Which Enhances the Activity of Frontocortical Dopaminergic and Adrenergic Pathways (Journal of Pharmacology and Experimental Therapeutics, 2003)
- Determination of the dose of agomelatine, a melatoninergic agonist and selective 5-HT2C antagonist, in the treatment of major depressive disorder: a placebo-controlled dose range study (International Clinical Psychopharmacology, 2002)
- Placebo-controlled trial of agomelatine in the treatment of major depressive disorder. (European Neuropsychopharmacology, 2006)
- Agomelatine, a new antidepressant, induces regional changes in hippocampal neurogenesis. (Biological Psychiatry, 2006)
- Agomelatine, the first melatonergic antidepressant: discovery, characterization and development (Nature Reviews Drug Discovery, 2010)
- Effect of Agomelatine in the Chronic Mild Stress Model of Depression in the Rat (Neuropsychopharmacology, 2003)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OC
-
InChIKeyYJYPHIXNFHFHND-UHFFFAOYSA-N
- Pubchem - Agomelatine
- Wikipedia - agomelatine
Agomelatine (brand names Valdoxan, Melitor, Thymanax) is an atypical antidepressant developed by the pharmaceutical company Servier. It is marketed for the treatment of major depressive disorder, primarily for its relatively favorable side effect profile: it avoids the weight gain, sexual dysfunction, and severe withdrawal associated with the most commonly used classes of antidepressants (SSRIs, SNRIs, tricyclics), while providing similar therapeutic benefit. Due to its distinctive mechanism of action, agomelatine is also studied for its effects on sleep regulation.
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Agomelatine
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