| Weight | 505.699 g/mol |
|---|---|
| Formula | C32H43NO4 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 1 |
Bardoxolone methyl (218600-53-4)
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- Sigma-Aldrich - Bardoxolone methyl105.00 - 360.50 USD
- Fisher Scientific - Search for Bardoxolone methyl
- TCI - Search for Bardoxolone methyl
- Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes (The New England Journal of Medicine, 2011)
- Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease (The New England Journal of Medicine, 2013)
- Effect of Bardoxolone Methyl on Kidney Function in Patients with T2D and Stage 3b-4 CKD (American Journal of Nephrology, 2011)
- A Phase I First-in-Human Trial of Bardoxolone Methyl in Patients with Advanced Solid Tumors and Lymphomas (Clinical Cancer Research, 2012)
- Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPAR, and HO-1 (American Journal of Physiology-renal Physiology, 2011)
- Analogs of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects (American Journal of Physiology-renal Physiology, 2013)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)C(=O)OC)C
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InChIKeyWPTTVJLTNAWYAO-UHFFFAOYSA-N
- Pubchem - Bardoxolone methyl
- Wikipedia - bardoxolone methyl
Bardoxolone methyl (also known as RTA 402, CDDO-methyl ester, and CDDO-Me) is an experimental and orally-bioavailable semi-synthetic triterpenoid, based on the scaffold of the natural product oleanolic acid. Pre-clinical studies indicate that the compound acts as an activator of the Nrf2 pathway and an inhibitor of the NF-B pathway. A phase 3 clinical trial evaluating bardoxolone methyl for the treatment of chronic kidney disease (CKD) was terminated in October 2012 after patients treated with the drug were found to have experienced a higher rate of heart-related adverse events, including heart failure, hospitalizations, and deaths.
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Bardoxolone methyl
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