| Weight | 400.529 g/mol |
|---|---|
| Formula | C19H20N4O2S2 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 4 |
Elesclomol (488832-69-5)
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- An Enhanced PET-Based Fluorescent Probe with Ultrasensitivity for Imaging Basal and Elesclomol-Induced HClO in Cancer Cells (Journal of the American Chemical Society, 2014)
- Elesclomol induces cancer cell apoptosis through oxidative stress (Molecular Cancer Therapeutics, 2008)
- Mitochondrial Electron Transport Is the Cellular Target of the Oncology Drug Elesclomol (PLOS ONE, 2012)
- Phase II, Randomized, Controlled, Double-Blinded Trial of Weekly Elesclomol Plus Paclitaxel Versus Paclitaxel Alone for Stage IV Metastatic Melanoma (Journal of Clinical Oncology, 2009)
- The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells. (Free Radical Biology and Medicine, 2012)
- Final Results of Phase III SYMMETRY Study: Randomized, Double-Blind Trial of Elesclomol Plus Paclitaxel Versus Paclitaxel Alone As Treatment for Chemotherapy-Naive Patients With Advanced Melanoma (Journal of Clinical Oncology, 2013)
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SMILESCN(C(=S)C1=CC=CC=C1)NC(=O)CC(=O)NN(C)C(=S)C2=CC=CC=C2
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InChIKeyBKJIXTWSNXCKJH-UHFFFAOYSA-N
- Pubchem - Elesclomol
- Wikipedia - elesclomol
Elesclomol (INN, codenamed STA-4783) is a drug that triggers apoptosis (programmed cell death) in cancer cells. It is being developed by Synta Pharmaceuticals and GlaxoSmithKline as a chemotherapy adjuvant, and has received both fast track and orphan drug status from the U.S. Food and Drug Administration for the treatment of metastatic melanoma.
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Elesclomol
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