| Weight | 1058.052 g/mol |
|---|---|
| Formula | C52H74Cl2O18 |
| Hydrogen Acceptors | 18 |
| Hydrogen Donors | 7 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 13 |
Fidaxomicin (873857-62-6)
Score:
#391 in Microbiology
,
#3061 in Biology
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- Fidaxomicin versus Vancomycin for Clostridium difficile Infection (The New England Journal of Medicine, 2011)
- Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial. (Lancet Infectious Diseases, 2012)
- Efficacy of Fidaxomicin Versus Vancomycin as Therapy for Clostridium difficile Infection in Individuals Taking Concomitant Antibiotics for Other Concurrent Infections (Clinical Infectious Diseases, 2011)
- Fidaxomicin Preserves the Intestinal Microbiome During and After Treatment of Clostridium difficile Infection (CDI) and Reduces Both Toxin Reexpression and Recurrence of CDI (Clinical Infectious Diseases, 2012)
- A new macrocyclic antibiotic, fidaxomicin (OPT- 80), causes less alteration to the bowel microbiota of Clostridium difficile-infected patients than does vancomycin (Microbiology, 2010)
- Treatment of First Recurrence of Clostridium difficile Infection: Fidaxomicin Versus Vancomycin (Clinical Infectious Diseases, 2012)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCC1C=C(C(CC=CC=C(C(=O)OC(CC=C(C=C(C1OC2C(C(C(C(O2)(C)C)OC(=O)C(C)C)O)O)C)C)C(C)O)COC3C(C(C(C(O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)C
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- Pubchem - Fidaxomicin
- Wikipedia - fidaxomicin
Fidaxomicin (trade names Dificid, Dificlir, and previously OPT-80 and PAR-101) is the first in a new class of narrow spectrum macrocyclic antibiotic drugs. It is a fermentation product obtained from the actinomycete Dactylosporangium aurantiacum subspecies hamdenesis. Fidaxomicin is non-systemic, meaning it is minimally absorbed into the bloodstream, it is bactericidal, and it has demonstrated selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.
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