Weight | 281.233 g/mol |
---|---|
Formula | C14H10F3NO2 |
Hydrogen Acceptors | 2 |
Hydrogen Donors | 2 |
Aromatic Rings | 2 |
Rotatable Bonds | 3 |
flufenamic acid (530-78-9)
Dignodolin
Score:
#609 in Neuroscience
,
#2734 in Biology
,
#3429 in Chemistry
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- Sigma-Aldrich - flufenamic acid19.40 - 65.80 USD
- Fisher Scientific - Search for flufenamic acid
- TCI - flufenamic acid36.00 - 310.00 USD
- Flufenamic acid, mefenamic acid and niflumic acid inhibit single nonselective cation channels in the rat exocrine pancreas (FEBS Letters, 1990)
- Flufenamic acid is a pH-dependent antagonist of TRPM2 channels (Neuropharmacology, 2004)
- Influence of Nanoencapsulation on Human Skin Transport of Flufenamic Acid (Skin Pharmacology and Physiology, 2006)
- Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid (Bioorganic & Medicinal Chemistry, 1999)
- Determination of diclofenac sodium, flufenamic acid, indomethacin and ketoprofen by LC-APCI-MS. (Journal of Pharmaceutical and Biomedical Analysis, 2001)
- Relationship of the Enterohepatic Cycle to Ulcerogenesis in the Rat Small Bowel with Flufenamic Acid (Gastroenterology, 1970)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Dignodolin
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SMILESC1=CC=C(C(=C1)C(=O)O)NC2=CC=CC(=C2)C(F)(F)F
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InChIKeyLPEPZBJOKDYZAD-UHFFFAOYSA-N
- Pubchem - flufenamic acid
- Wikipedia - flufenamic acid
Flufenamic acid is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins. Flufenamic acid is known to bind to and reduce the activity of prostaglandin F synthase and activate TRPC6. It is not widely used in humans as it has a high rate (30-60%) of gastrointestinal side effects.
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