| Weight | 312.417 g/mol |
|---|---|
| Formula | C18H24N4O |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 2 |
granisetron (109889-09-0)
Kytril · Granisetron Hydrochloride · BRL 43694
Score:
#528 in Neuroscience
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#918 in Biochemistry
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#2429 in Biology
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#3022 in Chemistry
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- Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy, randomised, comparative phase III trial (Lancet Oncology, 2009)
- Prevention of Cisplatin-Induced Emesis by the Oral Neurokinin-1 Antagonist, MK-869, in Combination With Granisetron and Dexamethasone or With Dexamethasone Alone (Journal of Clinical Oncology, 2001)
- Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron). (European Journal of Pharmacology, 1989)
- Reduction of rectal sensitivity and post-prandial motility by granisetron, a 5-HT3-receptor antagonist, in patients with irritable bowel syndrome (Alimentary Pharmacology & Therapeutics, 2007)
- Prophylactic antiemetic therapy with ondansetron, tropisetron, granisetron and metoclopramide in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind comparison with placebo (Canadian Journal of Anaesthesia-journal Canadien D Anesthesie, 1996)
- A pharmacokinetic study of granisetron (BRL 43694A), a selective 5-HT3 receptor antagonist: correlation with anti-emetic response (Cancer Chemotherapy and Pharmacology, 1989)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Kytril
- Granisetron Hydrochloride
- BRL 43694
- 1-Methyl-N-(endo-9-Methyl-9-Azabicyclo(3.3.1)non-3-yl)-1H-Indazole-3-Carboxamide
- BRL-43694
- BRL-43694A
- BRL43694
- BRL43694A
- Granisetron Monohydrochloride
- BRL 43694A
-
SMILESCN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C
-
InChIKeyMFWNKCLOYSRHCJ-UHFFFAOYSA-N
- Pubchem - granisetron
- Wikipedia - Granisetron
Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. It does not have much effect on vomiting due to motion sickness.
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