| Weight | 292.213 g/mol |
|---|---|
| Formula | C11H11F3N2O4 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 3 |
Hydroxyflutamide (52806-53-8)
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- Androgen Receptor Antagonist versus Agonist Activities of the Fungicide Vinclozolin Relative to Hydroxyflutamide (Journal of Biological Chemistry, 1995)
- Comparison of the Pharmacological Effects of a Novel Selective Androgen Receptor Modulator, the 5-Reductase Inhibitor Finasteride, and the Antiandrogen Hydroxyflutamide in Intact Rats: New Approach for Benign Prostate Hyperplasia (Endocrinology, 2004)
- Agonist and antagonist activities of hydroxyflutamide and casodex relate to androgen receptor stabilization (Urology, 1996)
- Hydroxyflutamide may not always be a pure antiandrogen (The Lancet, 1997)
- The AntiAndrogen Hydroxyflutamide and Androgens Inhibit Interleukin6 Production by an AndrogenResponsive Human Osteoblastic Cell Line (Journal of Bone and Mineral Research, 1999)
- Inhibition of rat testicular 17-hydroxylase and 17,20-lyase activities by anti-androgens (flutamide, hydroxyflutamide, ru23908, cyproterone acetate) in vitro (Journal of Steroid Biochemistry, 1987)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(C)(C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F)O
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InChIKeyYPQLFJODEKMJEF-UHFFFAOYSA-N
- Pubchem - Hydroxyflutamide
- Wikipedia - hydroxyflutamide
Hydroxyflutamide (HF, OHF) (developmental code name SCH-16423), or 2-hydroxyflutamide, is a nonsteroidal antiandrogen (NSAA). It is the major active metabolite of flutamide. It is reported to possess an IC50 of 700 nM for the androgen receptor (AR), about 4-fold less than that of bicalutamide.
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