| Weight | 293.725 g/mol |
|---|---|
| Formula | C15H13ClFNO2 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 4 |
Lumiracoxib (220991-20-8)
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- Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: Randomised controlled trial (The Lancet, 2004)
- Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomised controlled trial. (The Lancet, 2004)
- A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury (Nature Genetics, 2010)
- Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation. (Health Technology Assessment, 2008)
- Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2 (British Journal of Pharmacology, 2005)
- Cardiovascular outcomes in high-risk patients with osteoarthritis treated with Ibuprofen, Naproxen, or Lumiracoxib. (Annals of the Rheumatic Diseases, 2007)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1=CC(=C(C=C1)NC2=C(C=CC=C2Cl)F)CC(=O)O
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- Pubchem - Lumiracoxib
- Wikipedia - lumiracoxib
Lumiracoxib (rINN) is a carboxylic acid COX-2 selective inhibitor nonsteroidal anti-inflammatory drug, manufactured by Novartis and still sold in few countries, including Mexico, Ecuador and the Dominican Republic, under the trade name Prexige (sometimes misquoted as "Prestige" by the media). Lumiracoxib has several distinctive features. Its structure is different from that of other COX-2 inhibitors, such as celecoxib: lumiracoxib is an analogue of diclofenac (one chlorine substituted by fluorine, the phenylacetic acid has another methyl group in meta position), making it a member of the arylalkanoic acid class of NSAIDs; it binds to a different site on the COX-2 enzyme than do other COX-2 inhibitors; it is the only acidic coxib and has the highest COX-2 selectivity of any NSAID.
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