| Weight | 167.296 g/mol |
|---|---|
| Formula | C11H21N |
| Hydrogen Acceptors | 1 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 1 |
mecamylamine (60-40-2, 826-39-1)
Score:
#655 in Neuroscience
,
#1150 in Biochemistry
,
#2920 in Biology
,
#3659 in Chemistry
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- Analysis of Mecamylamine Stereoisomers on Human Nicotinic Receptor Subtypes (Journal of Pharmacology and Experimental Therapeutics, 2001)
- Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone (Clinical Pharmacology & Therapeutics, 1994)
- Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome. (Brain Research, 1998)
- Effects of mecamylamine on human cigarette smoking and subjective ratings (Journal of Pharmacology and Experimental Therapeutics, 1986)
- Voluntary ethanol intake in the rat and the associated accumbal dopamine overflow are blocked by ventral tegmental mecamylamine (European Journal of Pharmacology, 1998)
- The mesolimbic dopamine-activating properties of ethanol are antagonized by mecamylamine (European Journal of Pharmacology, 1993)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1(C2CCC(C2)C1(C)NC)C
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InChIKeyIMYZQPCYWPFTAG-UHFFFAOYSA-N
- Pubchem - mecamylamine
- Wikipedia - mecamylamine
Mecamylamine (INN, BAN; or mecamylamine hydrochloride (USAN); brand names Inversine, Vecamyl) is a non-selective, non-competitive antagonist of the nicotinic acetylcholine receptors (nAChRs) that was introduced in the 1950s as an antihypertensive drug. In the United States, it was voluntarily withdrawn from the market in 2009 but was brought to market in 2013 as Vecamyl and eventually was marketed by Turing Pharmaceuticals. Chemically, mecamylamine is a secondary aliphatic amine, with a pKaH of 11.2
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