| Weight | 182.081 g/mol |
|---|---|
| Formula | C4H9NO2Se |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 3 |
Methylselenocysteine (26046-90-2)
Score:
#1830 in Biochemistry
,
#3974 in Biology
,
#5003 in Chemistry
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- Sigma-Aldrich - Search for Methylselenocysteine
- Fisher Scientific - Search for Methylselenocysteine
- TCI - Search for Methylselenocysteine
- Production of Se-methylselenocysteine in transgenic plants expressing selenocysteine methyltransferase. (BMC Plant Biology, 2004)
- Elemental Selenium at Nano Size (Nano-Se) as a Potential Chemopreventive Agent with Reduced Risk of Selenium Toxicity: Comparison with Se-Methylselenocysteine in Mice (Toxicological Sciences, 2008)
- Methioninase and selenomethionine but not Se-methylselenocysteine generate methylselenol and superoxide in an in vitro chemiluminescent assay: implications for the nutritional carcinostatic activity of selenoamino acids. (Biochemical Pharmacology, 2004)
- Se-methylselenocysteine: a new compound for chemoprevention of breast cancer. (Nutrition and Cancer, 2001)
- Characterization of the Biological Activity of {{gamma}}-Glutamyl-Se- methylselenocysteine: A Novel, Naturally Occurring Anticancer Agent from Garlic (Cancer Research, 2001)
- Dimethyldiselenide and Methylseleninic Acid Generate Superoxide in an In Vitro Chemiluminescence Assay in the Presence of Glutathione: Implications for the Anticarcinogenic Activity of L-Selenomethionine and L-Se-Methylselenocysteine (Nutrition and Cancer, 2001)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC[Se]CC(C(=O)O)N
-
InChIKeyXDSSPSLGNGIIHP-UHFFFAOYSA-N
- Pubchem - Methylselenocysteine
- Wikipedia - Se-methylselenocysteine
Methylselenocysteine, also known as Se-methylselenocysteine, is an analog of S-methylcysteine in which the sulfur atom is replaced with a selenium atom. It is an inhibitor of DMBA-induced mammary tumors and a "chemopreventive agent that blocks cell cycle progression and proliferation of premalignant mammary lesions and induces apoptosis of cancer cell lines in culture." Apoptosis has been proposed as the most plausible mechanism for the chemopreventive activities of selenocompounds. Se-Methylselenocysteine was more efficient at inducing apoptosis than selenite, but was less toxic." The "selenite-induced cell death could be derived from necrosis rather than apoptosis, since selenite did not significantly induce several apoptotic phenomena, including the activation of caspase-3." In the Nutritional Prevention of Cancer Trial, selenized yeast resulted in "a reduction in the incidence of prostate cancer and in total cancer incidence"; subsequent anti-cancer studies using selenomethionine did not show any benefit against cancer; but, selenized yeast contains both selenomethionine and methylselenocysteine.
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