Weight | 148.158 g/mol |
---|---|
Formula | C6H12O4 |
Hydrogen Acceptors | 3 |
Hydrogen Donors | 3 |
Aromatic Rings | 0 |
Rotatable Bonds | 4 |
mevalonic acid (150-97-0)
Score:
#989 in Biochemistry
,
#2599 in Biology
,
#3245 in Chemistry
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- Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and swiss 3T3 cells stimulated to divide by platelet-derived growth factor. (Journal of Biological Chemistry, 1980)
- Evidence for modification of lamin B by a product of mevalonic acid. (Journal of Biological Chemistry, 1988)
- Evidence for post-translational incorporation of a product of mevalonic acid into Swiss 3T3 cell proteins. (Journal of Biological Chemistry, 1984)
- A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. (British Journal of Pharmacology, 2001)
- Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. (Journal of Biological Chemistry, 1994)
- Liquid chromatography/tandem mass spectrometry methods for quantitation of mevalonic acid in human plasma and urine: method validation, demonstration of using a surrogate analyte, and demonstration of unacceptable matrix effect in spite of use of a stable isotope analog internal standard (Rapid Communications in Mass Spectrometry, 2003)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(CCO)(CC(=O)O)O
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InChIKeyKJTLQQUUPVSXIM-UHFFFAOYSA-N
- Pubchem - mevalonic acid
- Wikipedia - Mevalonic acid
Mevalonic acid (MVA) is a key organic compound in biochemistry; the name is a contraction of dihydroxymethylvalerolactone. The carboxylate anion of mevalonic acid, which is the predominant form in biological environments, is known as mevalonate and is of major pharmaceutical importance. Drugs like statins (which lower levels of cholesterol) stop the production of mevalonate by inhibiting HMG-CoA reductase.
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