| Weight | 146.19 g/mol |
|---|---|
| Formula | C6H14N2O2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 4 |
Mildronate (76144-81-5)
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- Mildronate: Cardioprotective Action through Carnitine-Lowering Effect (Trends in Cardiovascular Medicine, 2002)
- The Carnitine Transporter SLC22A5 Is Not a General Drug Transporter, but It Efficiently Translocates Mildronate (Drug Metabolism and Disposition, 2009)
- Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction. (Journal of Cardiovascular Pharmacology, 2006)
- Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats (British Journal of Pharmacology, 2009)
- Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart (Life Sciences, 2008)
- Mildronate, a novel fatty acid oxidation inhibitor and antianginal agent, reduces myocardial infarct size without affecting hemodynamics. (Journal of Cardiovascular Pharmacology, 2006)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC[N+](C)(C)NCCC(=O)[O-]
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InChIKeyPVBQYTCFVWZSJK-UHFFFAOYSA-N
- Pubchem - Mildronate
- Wikipedia - meldonium
Meldonium (INN), trade-named as Mildronate among others, is a limited-market pharmaceutical, developed in 1970 by Ivars Kalvi at the USSR Latvia Institute of Organic Synthesis, and now manufactured by the Latvian pharmaceutical company Grindeks and several generic manufacturers. It is primarily distributed in Eastern European countries as an anti-ischemia medication. Since 1 January 2016, it has been on the World Anti-Doping Agency (WADA) list of substances banned from use by athletes.
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Mildronate
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