| Weight | 195.693 g/mol |
|---|---|
| Formula | C11H14ClN |
| Hydrogen Acceptors | 1 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 3 |
Pargyline hydrochloride (306-07-0)
Pargyline
Score:
#969 in Neuroscience
,
#4265 in Biology
,
#5377 in Chemistry
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- Pargyline prevents MPTP-induced parkinsonism in primates (Science, 1984)
- Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in monkeys (European Journal of Pharmacology, 1984)
- Comparative behavioral effects of clorgyline and pargyline in man: A preliminary evaluation (Psychopharmacology, 1979)
- Effects of Transient Forebrain Ischemia and Pargyline on Extracellular Concentrations of Dopamine, Serotonin, and Their Metabolites in the Rat Striatum as Determined by In Vivo Microdialysis (Journal of Neurochemistry, 1990)
- THE EFFECTS OF CHRONIC REGIMENS OF CLORGYLINE AND PARGYLINE ON MONOAMINE METABOLISM IN THE RAT BRAIN (Journal of Neurochemistry, 1979)
- Mitochondrial Monoamine Oxidase INACTIVATION BY PARGYLINE. ADDUCT FORMATION (Journal of Biological Chemistry, 1974)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Pargyline
-
SMILESCN(CC#C)CC1=CC=CC=C1.Cl
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InChIKeyBCXCABRDBBWWGY-UHFFFAOYSA-N
- Pubchem - Pargyline hydrochloride
- Wikipedia - pargyline hydrochloride
Pargyline (brand name Eutonyl) is an irreversible selective monoamine oxidase (MAO)-B inhibitor drug (IC50 for MAO-A is 0.01152 mol/L and for MAO-B is 0.00820 mol/L) It was brought to market in the US and the UK by Abbott in 1963 as an antihypertensive drug branded "Eutonyl". It was one of several MAO inhibitors introduced in the 1960s including nialamide, isocarboxazid, phenelzine, and tranylcypromine. By 2007 the drug was discontinued and as of 2014 there were no generic versions available in the US.
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Pargyline hydrochloride
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