| Weight | 461.668 g/mol |
|---|---|
| Formula | C25H52NO4P |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 20 |
Perifosine (157716-52-4)
Score:
#72 in Molecular and cellular biology
,
#2099 in Biochemistry
,
#5481 in Chemistry
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- Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells (Blood, 2006)
- Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation (Molecular Cancer Therapeutics, 2003)
- Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts (Blood, 2007)
- Coadministration of Histone Deacetylase Inhibitors and Perifosine Synergistically Induces Apoptosis in Human Leukemia Cells through Akt and ERK1/2 Inactivation and the Generation of Ceramide and Reactive Oxygen Species (Cancer Research, 2005)
- Perifosine Inhibits Multiple Signaling Pathways in Glial Progenitors and Cooperates With Temozolomide to Arrest Cell Proliferation in Gliomas In vivo (Cancer Research, 2005)
- Perifosine: Update on a novel Akt inhibitor (Current Oncology Reports, 2009)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](CC1)(C)C
-
InChIKeySZFPYBIJACMNJV-UHFFFAOYSA-N
- Pubchem - Perifosine
- Wikipedia - perifosine
Perifosine (also KRX-0401) is a drug candidate being developed for a variety of cancer indications. It is an alkyl-phospholipid structurally related to miltefosine. It acts as an Akt inhibitor and a PI3K inhibitor.
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Perifosine
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