| Weight | 378.472 g/mol |
|---|---|
| Formula | C23H26N2O3 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 6 |
Pravadoline (92623-83-1)
"What do you need help with?"
LabBot
- Sigma-Aldrich - Search for Pravadoline
- Fisher Scientific - Search for Pravadoline
- TCI - Search for Pravadoline
- Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor. (Journal of Medicinal Chemistry, 1992)
- Pharmacology of pravadoline: a new analgesic agent. (Journal of Pharmacology and Experimental Therapeutics, 1990)
- Nephrotoxicity of Pravadoline Maleate (WIN 48098-6) in Dogs: Evidence of Maleic Acid-Induced Acute Tubular Necrosis (Toxicological Sciences, 1993)
- Pravadoline: profile in isolated tissue preparations. (Journal of Pharmacology and Experimental Therapeutics, 1990)
- Studies of the conformational properties of the cannabimimetic aminoalkylindole pravadoline using NMR and molecular modeling (European Journal of Medicinal Chemistry, 1995)
- Pravadoline and aminoalkylindole (AAI) analogues: actions which suggest a receptor interaction. (British Journal of Pharmacology, 1989)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1=C(C2=CC=CC=C2N1CCN3CCOCC3)C(=O)C4=CC=C(C=C4)OC
-
InChIKeyMEUQWHZOUDZXHH-UHFFFAOYSA-N
- Pubchem - Pravadoline
- Wikipedia - pravadoline
Pravadoline (WIN 48,098) is an antiinflammatory and analgesic drug with an IC50 of 4.9M and a Ki of 2511nM at CB1, related in structure to nonsteroidal anti-inflammtory drugs (NSAIDs) such as indometacin. It was developed in the 1980s as a new antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX). However, pravadoline was found to exhibit unexpectedly strong analgesic effects, which appeared at doses ten times smaller than the effective anti-inflammatory dose and so could not be explained by its action as a COX inhibitor.
Suppliers
Most-cited Publications
Safety
Alternate Names
External Links
Similar Compounds
436087-08-0
(436087-08-0)
1 alternate name
3 suppliers
2-(3-formyl-2-methyl-1H-indol-1-yl)acetamide
(61922-00-7)
1 alternate name
3 suppliers
433955-84-1
(433955-84-1)
1 alternate name
3 suppliers
1-Allyl-2-methyl-1H-indole-3-carbaldehyde
(230283-19-9)
1 alternate name
3 suppliers
2-methyl-1-[2-(2-methylpiperidin-1-yl)-2-oxoethyl]-1H-indole-3-carbaldehyde
(498560-54-6)
1 alternate name
3 suppliers
1-Ethyl-2-methyl-1H-indole-3-carbaldehyde
(66727-64-8)
1 alternate name
3 suppliers
436096-87-6
(436096-87-6)
1 alternate name
3 suppliers
1-ISOBUTYL-2-METHYL-1H-INDOLE-3-CARBALDEHYDE
(714278-20-3)
1 alternate name
3 suppliers
ethyl (3-formyl-2-methyl-1H-indol-1-yl)acetate
(433307-59-6)
1 alternate name
3 suppliers
433963-38-3
(433963-38-3)
1 alternate name
3 suppliers
(3-formyl-2-methyl-1H-indol-1-yl)acetic acid
(432001-45-1)
1 alternate name
3 suppliers
5-Methoxy-1,2-dimethyl-1H-indole-3-carboxylic acid
(105909-93-1)
1 alternate name
3 suppliers
2-Methyl-1-prop-2-ynyl-1H-indole-3-carbaldehyde
(842973-82-4)
1 alternate name
3 suppliers
methyl (3-formyl-2-methyl-1H-indol-1-yl)acetate
(431983-71-0)
1 alternate name
3 suppliers
6-Bromo-5-Methoxy-1,2-Dimethyl-1H-Indole-3-Carbaldehyde
(111083-32-0)
1 alternate name
3 suppliers
50292-91-6
(50292-91-6)
1 alternate name
3 suppliers
40945-79-7
(40945-79-7)
1 alternate name
3 suppliers
5-Hydroxy-1,2-dimethyl-1H-indole-3-carboxylic acid
(25888-01-1)
1 alternate name
3 suppliers
Mecarbinate
(15574-49-9)
1 alternate name
3 suppliers
2-chloro-1-(5-methoxy-1,2-dimethyl-1H-indol-3-yl)ethanone
(113369-47-4)
1 alternate name
3 suppliers
1,2,6-Trimethyl-1H-indole-3-carbaldehyde
(842971-69-1)
1 alternate name
3 suppliers
1,2-Dimethyl-1H-indole-3-carbaldehyde
(38292-40-9)
1 alternate name
3 suppliers
AC1LG8FI
(315247-81-5)
1 alternate name
3 suppliers
Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate
(110543-98-1)
1 alternate name
3 suppliers
Incazane
(53734-79-5)
1 alternate name
3 suppliers
69898-40-4
(69898-40-4)
1 alternate name
3 suppliers
BML-190
(2854-32-2)
1 alternate name
3 suppliers
1-[2-(4-fluorophenoxy)ethyl]-1H-indole-3-carbaldehyde
(340318-78-7)
1 alternate name
3 suppliers
1-[2-(3,5-dimethylphenoxy)ethyl]-1H-indole-3-carbaldehyde
(884497-57-8)
1 alternate name
3 suppliers
354993-58-1
(354993-58-1)
1 alternate name
3 suppliers
27387-31-1
(27387-31-1)
1 alternate name
3 suppliers
1-[2-(2-methoxyphenoxy)ethyl]-1H-indole-3-carbaldehyde
(299936-03-1)
1 alternate name
3 suppliers
2-(3-Formyl-indol-1-yl)-N-(2-methoxy-ethyl)-acetamide
(347319-85-1)
1 alternate name
3 suppliers
N-Benzo[1,3]dioxol-5-yl-2-(3-formyl-indol-1-yl)-acetamide
(294889-52-4)
1 alternate name
3 suppliers
1-(1,2-dimethyl-1H-indol-3-yl)ethanone
(33022-90-1)
1 alternate name
3 suppliers
1-[2-(2-methylphenoxy)ethyl]-1H-indole-3-carbaldehyde
(299935-67-4)
1 alternate name
3 suppliers
1-Benzyl-2-methyl-1H-indole-3-carbaldehyde
(95202-45-2)
1 alternate name
3 suppliers
AC1LK3MJ
(315248-20-5)
1 alternate name
3 suppliers
40313-28-8
(40313-28-8)
1 alternate name
3 suppliers
1-[2-(2-fluorophenoxy)ethyl]-1H-indole-3-carbaldehyde
(309732-86-3)
1 alternate name
3 suppliers
ZINC00086820
(441314-01-8)
1 alternate name
3 suppliers
(3-Cyano-2-methyl-indol-1-yl)-acetic acid
(531544-17-9)
1 alternate name
3 suppliers
23690-80-4
(23690-80-4)
1 alternate name
3 suppliers
131707-24-9
(131707-24-9)
1 alternate name
3 suppliers
1-[2-(2-chlorophenoxy)ethyl]-1H-indole-3-carbaldehyde
(340318-80-1)
1 alternate name
3 suppliers
1-(2-fluorobenzyl)-2-methyl-1H-indole-3-carbaldehyde
(347323-87-9)
1 alternate name
3 suppliers
Pirlindole hydrochloride
(16154-78-2, 60762-57-4)
1 alternate name
3 suppliers
1,2,3-Trimethyl-1H-indole-5-carboxylic acid
(356773-97-2)
1 alternate name
3 suppliers
Arbidol
(131707-25-0)
1 alternate name
3 suppliers
2-methyl-1-(4-nitrobenzyl)-1H-indole-3-carbaldehyde
(591210-36-5)
1 alternate name
3 suppliers
Tetrindole
(135991-95-6)
1 alternate name
3 suppliers
436087-09-1
(436087-09-1)
1 alternate name
3 suppliers
2-(3-Formyl-indol-1-yl)-N-isopropyl-acetamide
(708284-70-2)
1 alternate name
3 suppliers
2-[(1-methyl-1h-indol-3-yl)methyl]benzoic acid
(6642-47-3)
1 alternate name
3 suppliers
6951-67-3
(6951-67-3)
1 alternate name
3 suppliers
347319-95-3
(347319-95-3)
1 alternate name
3 suppliers
STK045740
1 alternate name
3 suppliers
5-bromo-1-(2-oxo-2-pyrrolidin-1-ylethyl)-1H-indole-3-carbaldehyde
(434299-46-4)
1 alternate name
3 suppliers
1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-1H-indole-3-carbaldehyde
(347320-62-1)
1 alternate name
3 suppliers
AC1LIBZQ
(640260-00-0)
1 alternate name
3 suppliers
2-(5-bromo-3-formyl-1H-indol-1-yl)-N-(2-furylmethyl)acetamide
(434299-98-6)
1 alternate name
3 suppliers
N-cyclopropyl-2-(3-formyl-1H-indol-1-yl)acetamide
(530121-56-3)
1 alternate name
3 suppliers
5-methoxy-1-methyl-1H-indole-3-carbaldehyde
(39974-94-2)
1 alternate name
3 suppliers
1,3,7-trimethyl-1H-indole-2-carboxylic acid
(1015846-77-1)
1 alternate name
3 suppliers
1-benzyl-2,3-dimethyl-1H-indole-5-carbohydrazide
(350990-21-5)
1 alternate name
3 suppliers
1-Benzyl-2,3-dimethyl-1H-indole-5-carboxylic acid
(313498-12-3)
1 alternate name
3 suppliers
1,3-dimethyl-1H-indole-2-carboxylic acid
(204919-54-0)
1 alternate name
3 suppliers
5-fluoro-1,3-dimethyl-1H-indole-2-carboxylic acid
(854531-33-2)
1 alternate name
3 suppliers
6637-15-6
(6637-15-6)
1 alternate name
3 suppliers
431981-28-1
(431981-28-1)
1 alternate name
3 suppliers
1-(1,3-dimethyl-1H-indol-2-yl)-1-butanone
(425373-45-1)
1 alternate name
3 suppliers
2-(3-formyl-1H-indol-1-yl)acetamide
(312973-43-6)
1 alternate name
3 suppliers
1-(3,4-Methylenedioxyphenyl) tetrahydronorharman hydrochloride
(3380-75-4)
1 alternate name
3 suppliers
1-(4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-beta-carboline hydrochloride
(3489-15-4)
1 alternate name
3 suppliers
2-benzoyl-1H-indole-3-carboxylic acid
(74588-82-2)
1 alternate name
3 suppliers
ethyl 3-formyl-5-methoxy-1H-indole-2-carboxylate
(36820-78-7)
1 alternate name
3 suppliers
6-Methoxy-1-methyl-1H-indole-3-carbaldehyde
(202807-44-1)
1 alternate name
3 suppliers
go 6983
(133053-19-7)
1 alternate name
3 suppliers
1-(3-methoxybenzyl)-1H-indole-3-carbaldehyde
(261637-72-3)
1 alternate name
3 suppliers
2-chloro-1-ethyl-1H-indole-3-carbaldehyde
(64788-54-1)
1 alternate name
3 suppliers
2-(3-ACETYL-1H-INDOL-1-YL)ACETAMIDE
(799264-84-9)
1 alternate name
3 suppliers
6,9-dimethyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine
(1119451-37-4)
1 alternate name
3 suppliers
Diazoline
(6153-33-9)
1 alternate name
3 suppliers
2-(5-bromo-3-formyl-1H-indol-1-yl)acetamide
(510716-35-5)
1 alternate name
3 suppliers
2-(3-formyl-1H-indol-1-yl)butanoic acid
(869947-42-2)
1 alternate name
3 suppliers
1-Allyl-1H-indole-3-carbaldehyde
(111480-86-5)
1 alternate name
3 suppliers
(3-Cyclopropanecarbonyl-indol-1-yl)-acetic acid
(708295-12-9)
1 alternate name
3 suppliers
64788-55-2
(64788-55-2)
1 alternate name
3 suppliers
2-(3-ACETYL-1H-INDOL-1-YL)BUTANOIC ACID
(869949-98-4)
1 alternate name
3 suppliers
7598-91-6
(7598-91-6)
1 alternate name
3 suppliers
N-benzyl-1-pentyl-1H-indole-3-carboxamide
(695213-59-3)
1 alternate name
3 suppliers
1H-Indole-1-propanamide, 3-formyl-
(61922-01-8)
1 alternate name
3 suppliers
27065-94-7
(27065-94-7)
1 alternate name
3 suppliers
2-Methyl-1-benzyltryptamine
(18690-56-7)
1 alternate name
3 suppliers
Pravadoline
CAS Directory
