| Weight | 128.156 g/mol |
|---|---|
| Formula | C4H4N2OS |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 1 |
Thiazole-4-carboxamide (3575-09-5)
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- Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. (Journal of Medicinal Chemistry, 2004)
- 2-Aminothiazole as a Novel Kinase Inhibitor Template. StructureActivity Relationship Studies toward the Discovery of N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (Dasatinib, BMS-354825) as a Potent pan-Src Kinase Inhibitor (Journal of Medicinal Chemistry, 2006)
- Initial studies on the mechanism of action of a new oncolytic thiazole nucleoside, 2--d-ribofuranosylthiazole-4-carboxamide NSC 286193) (Biochemical Pharmacology, 1982)
- Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin (Biochemistry, 1994)
- Thiazole-4-carboxamide adenine dinucleotide (TAD). Analogues stable to phosphodiesterase hydrolysis (Journal of Medicinal Chemistry, 1986)
- Synthesis of thiazole-4-carboxamide adenine dinucleotide. A powerful inhibitor of IMP dehydrogenase (Journal of Medicinal Chemistry, 1983)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1=C(N=CS1)C(=O)N
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InChIKeyPQQRHWFRZHFGFM-UHFFFAOYSA-N
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