| Weight | 264.325 g/mol |
|---|---|
| Formula | C14H20N2O3 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 8 |
Vorinostat (149647-78-9)
Score:
#210 in Biochemistry
,
#838 in Biology
,
#926 in Chemistry
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- Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug (Nature Biotechnology, 2007)
- Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL) (Blood, 2007)
- Phase IIB Multicenter Trial of Vorinostat in Patients With Persistent, Progressive, or Treatment Refractory Cutaneous T-Cell Lymphoma (Journal of Clinical Oncology, 2007)
- FDA Approval Summary: Vorinostat for Treatment of Advanced Primary Cutaneous T-Cell Lymphoma (Oncologist, 2007)
- Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy (Nature, 2012)
- Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes (Blood, 2007)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO
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InChIKeyWAEXFXRVDQXREF-UHFFFAOYSA-N
- Pubchem - Vorinostat
- Wikipedia - vorinostat
Vorinostat (rINN) also known as suberanilohydroxamic acid (suberoyl+anilide+hydroxamic acid abbreviated as SAHA) is a member of a larger class of compounds that inhibit histone deacetylases (HDAC). Histone deacetylase inhibitors (HDI) have a broad spectrum of epigenetic activities. Vorinostat is marketed under the name Zolinza ( zoh-LIN-z) by Merck for the treatment of cutaneous manifestations in patients with cutaneous T cell lymphoma (CTCL) when the disease persists, gets worse, or comes back during or after two systemic therapies.
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Vorinostat
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