| Weight | 239.322 g/mol |
|---|---|
| Formula | C15H17N3 |
| Hydrogen Acceptors | 1 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 2 |
1,3-Di-o-tolylguanidine (97-39-2)
1,3-ditolylguanidine hydrochloride · 1,3-di-ortho-tolyl-guanidine · N,N'-bis(2-methylphenyl)guanidine
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- Sigma-Aldrich - 1,3-Di-o-tolylguanidine37.80 - 77.00 USD
- Fisher Scientific - Search for 1,3-Di-o-tolylguanidine
- TCI - 1,3-Di-o-tolylguanidine25.00 - 108.00 USD
- Autoradiographic distribution of [3H](+)-pentazocine and [3H]1,3-di-o-tolylguanidine (DTG) binding sites in guinea pig brain: a comparative study (Brain Research, 1992)
- SIGMA1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 Di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats (Polish Journal of Pharmacology, 2003)
- Effects of subcutaneous and intracerebroventricular administration of the sigma receptor ligand 1,3-Di-o-tolylguanidine on body temperature in the rat: interactions with BMY 14802 and rimcazole. (Journal of Pharmacology and Experimental Therapeutics, 1991)
- Antinociception following 1,3,-di-o-tolylguanidine, a selective receptor ligand (Pharmacology, Biochemistry and Behavior, 1995)
- Effects of (+)-pentazocine and 1,3-di-o-tolylguanidine (DTG), sigma () ligands, on micturition in anaesthetized rats (British Journal of Pharmacology, 2000)
- The ligand 1,3-di-o-tolylguanidine depresses amino acid-induced excitation non-selectively in rat brain (European Journal of Pharmacology, 1992)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - H301: Toxic if swallowed
Danger Acute toxicity, oral - Category 3 - H361: Suspected of damaging fertility or the unborn child
Warning Reproductive toxicity - Category 2 - H373: Causes damage to organs through prolonged or repeated exposure
Warning Specific target organ toxicity, repeated exposure - Category 2 - 1,3-ditolylguanidine hydrochloride
- 1,3-di-ortho-tolyl-guanidine
- N,N'-bis(2-methylphenyl)guanidine
- 1,3-ditolylguanidine
- 1,3-di-(2-tolyl)guanidine
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SMILESCC1=CC=CC=C1NC(=NC2=CC=CC=C2C)N
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InChIKeyOPNUROKCUBTKLF-UHFFFAOYSA-N
- Pubchem - 1,3-Di-o-tolylguanidine
- Wikipedia - 1,3-di-O-tolylguanidine
Ditolylguanidine is a sigma receptor agonist. It is somewhat selective for sigma receptors, but non-selective between the two sigma receptor subtypes, binding to both 1 and 2 with equal affinity. It has neuroprotective and antidepressant effects, and potentiates the effects of NMDA antagonists.
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1,3-Di-o-tolylguanidine
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