4-PHENYLBUTYRIC ACID (1821-12-1)

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  25 g
  $24.00

  100 g
  $70.00

  500 g
  $288.00

Most-cited Publications

• In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR. (Journal of Clinical Investigation, 1997)
• A Pilot Clinical Trial of Oral Sodium 4-Phenylbutyrate (Buphenyl) in F508-Homozygous Cystic Fibrosis Patients (American Journal of Respiratory and Critical Care Medicine, 1998)
• Oral sodium phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial (Blood, 1995)
• Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice (Journal of Neurochemistry, 2005)
• Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate (Blood, 1994)
• A Phase I Dose Escalation and Bioavailability Study of Oral Sodium Phenylbutyrate in Patients with Refractory Solid Tumor Malignancies (Clinical Cancer Research, 2001)

Areas of Application

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Trends

Alternate Names

• sodium phenylbutyrate
• Buphenyl
• 4-phenylbutyric acid, sodium salt
• sodium 4-phenylbutanoate
• 4-phenylbutyrate
• Ammonaps
• 4-phenylbutyric acid, calcium salt
• sodium 4-phenylbutyrate
• SMILES
  C1=CC=C(C=C1)CCCC(=O)O
• InChIKey
  OBKXEAXTFZPCHS-UHFFFAOYSA-N

External Links

• Pubchem - 4-PHENYLBUTYRIC ACID
• Wikipedia - phenylbutyric acid
  Sodium phenylbutyrate is a salt of an aromatic fatty acid, 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid. The compound is used to treat urea cycle disorders, because its metabolites offer an alternative pathway to the urea cycle to allow excretion of excess nitrogen. It is an orphan drug, marketed by Ucyclyd Pharma under the trade name Buphenyl, by Swedish Orphan International (Sweden) as Ammonaps, and by Fyrlklvern Scandinavia as triButyrate.

Synthesis

benzene  +  4-CHLOROBUTYRIC ACID (Friedel-Crafts alkylation)

Synthesis of 4-PHENYLBUTYRIC ACID ›

Similar Compounds

4-(4-ethylphenyl)butanoic acid (5467-53-8)

9 alternate names

3 suppliers

4521-22-6 (4521-22-6)

9 alternate names

3 suppliers

Methyl 4-phenylbutyrate (2046-17-5)

9 alternate names

3 suppliers

4-(4-ISOPROPYLPHENYL)BUTANOIC ACID (7501-37-3)

9 alternate names

3 suppliers

2-methyl-4-phenylbutanoic acid (1949-41-3)

9 alternate names

3 suppliers

4-Phenyl-1-butanol (3360-41-6)

9 alternate names

3 suppliers

Ethyl 4-phenylbutanoate (10031-93-3)

9 alternate names

3 suppliers

4-(4-HYDROXYPHENYL)BUTANOIC ACID (7021-11-6)

9 alternate names

3 suppliers

4-(4-tert-butylphenyl)butanoic Acid (24475-36-3)

9 alternate names

3 suppliers

4-Phenylbutanal (18328-11-5)

9 alternate names

3 suppliers

4-(4-Aminophenyl)butyric acid (15118-60-2)

9 alternate names

3 suppliers

4-(4-Bromophenyl)butanoic acid (35656-89-4)

9 alternate names

3 suppliers

782-28-5 (782-28-5)

9 alternate names

3 suppliers

4-(4-Chlorophenyl)butyric acid (4619-18-5)

9 alternate names

3 suppliers

4-(4-fluorophenyl)butanoic acid (589-06-0)

9 alternate names

3 suppliers

6-Phenylhexanoic acid (5581-75-9)

9 alternate names

3 suppliers

7-Phenylheptanoic acid (40228-90-8)

9 alternate names

3 suppliers

15-Phenylpentadecanoic acid (40228-93-1)

9 alternate names

3 suppliers

8-Phenyloctanoic acid (26547-51-3)

9 alternate names

3 suppliers

12-Phenyldodecanoic acid (14507-27-8)

9 alternate names

3 suppliers

11-Phenylundecanoic acid (3343-24-6, 50696-68-9)

9 alternate names

3 suppliers

2-Hydroxy-4-phenylbutanoic acid (4263-93-8)

9 alternate names

3 suppliers

2-oxo-4-phenylbutanoic acid (710-11-2)

9 alternate names

3 suppliers

L-Homophenylalanine (943-73-7)

9 alternate names

3 suppliers

Methyl 4-(4-aminophenyl)butanoate (20637-09-6)

9 alternate names

3 suppliers

5-Phenylpentan-2-one (2235-83-8)

9 alternate names

3 suppliers

Benzenepentanal (36884-28-3)

9 alternate names

3 suppliers

4-(4-Methoxyphenyl)butyric acid (4521-28-2)

9 alternate names

3 suppliers

3-Benzoylpropionic acid (2051-95-8)

9 alternate names

3 suppliers

1,4-Diphenylbutane (1083-56-3)

9 alternate names

3 suppliers

4-phenylbutanamide (1199-98-0)

9 alternate names

3 suppliers

8-phenyloctan-1-ol (10472-97-6)

9 alternate names

3 suppliers

10-Phenyl-1-decanol (62607-69-6)

9 alternate names

3 suppliers

Benzeneheptanol (3208-25-1)

9 alternate names

3 suppliers

Pentylbenzene (538-68-1)

9 alternate names

3 suppliers

4-N-butyltoluene (1595-05-7)

9 alternate names

3 suppliers

6-Phenylhexan-3-one (58977-36-9)

9 alternate names

3 suppliers

5-Phenyl-1-pentyne (1823-14-9)

9 alternate names

3 suppliers

4-(4-phenoxyphenyl)butanoic acid (6958-94-7)

9 alternate names

3 suppliers

4-Phenyl-2-butanol (2344-70-9)

9 alternate names

3 suppliers

4-oxo-4-(4-propylphenyl)butanoic acid (57821-78-0)

9 alternate names

3 suppliers

4619-20-9 (4619-20-9)

9 alternate names

3 suppliers

4-(4-Ethylphenyl)-4-oxobutanoic acid (49594-75-4)

9 alternate names

3 suppliers

1-Bromo-4-phenylbutane (13633-25-5)

9 alternate names

3 suppliers

5-Phenyl-1-pentene (1075-74-7)

9 alternate names

3 suppliers

3-phenylcyclobutane-1-carboxylic acid (66016-28-2)

9 alternate names

3 suppliers

1-Phenyldecane (104-72-3)

9 alternate names

3 suppliers

1-Phenylheptadecane (14752-75-1)

9 alternate names

3 suppliers

TETRADECYLBENZENE (1459-10-5)

9 alternate names

3 suppliers

1-Phenyloctadecane (4445-07-2)

9 alternate names

3 suppliers

DODECYLBENZENE (123-01-3, 25265-78-5, 68442-69-3, 29986-57-0)

9 alternate names

3 suppliers

Nonylbenzene (79554-39-5, 68608-80-0, 1081-77-2)

9 alternate names

3 suppliers

OCTYLBENZENE (2189-60-8)

9 alternate names

3 suppliers

4-oxo-4-(4-pentylphenyl)butanoic acid (64779-07-3)

9 alternate names

3 suppliers

4251-21-2 (4251-21-2)

9 alternate names

3 suppliers

3-(4-ethylphenyl)propanoic Acid (64740-36-9)

9 alternate names

3 suppliers

Methyl 3-benzoylpropionate (25333-24-8)

9 alternate names

3 suppliers

3-Phenylpropan-1-ol (1335-12-2, 122-97-4, 93842-54-7)

9 alternate names

3 suppliers

Propylbenzene (103-65-1)

9 alternate names

3 safety hazards

3 suppliers

3-Phenylpropanal (104-53-0, 1335-10-0)

9 alternate names

3 suppliers

1-Phenylbutan-2-one (1007-32-5)

9 alternate names

3 suppliers

6947-81-5 (6947-81-5)

9 alternate names

3 suppliers

Benzene, (5-iodopentyl)- (99858-37-4)

9 alternate names

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(5-Bromopentyl)benzene (14469-83-1)

9 alternate names

3 suppliers

36440-58-1 (36440-58-1)

9 alternate names

3 suppliers

1-Methyl-3-phenylpropylamine (22374-89-6)

9 alternate names

3 suppliers

methyl 4-(4-methylphenyl)-4-oxobutanoate (57498-54-1)

9 alternate names

3 suppliers

ethyl 3-oxo-4-phenylbutanoate (718-08-1)

9 alternate names

3 suppliers

4-(4-Methoxyphenyl)-1-butanol (52244-70-9)

9 alternate names

3 suppliers

1-Phenylpentan-2-one (6683-92-7)

9 alternate names

3 suppliers

35288-08-5 (35288-08-5)

9 alternate names

3 suppliers

Benzenepropanal, 4-methyl- (5406-12-2)

9 alternate names

3 suppliers

Ethyl 4-oxo-4-phenylbutyrate (6270-17-3)

9 alternate names

3 suppliers

(6-Bromohexyl)benzene (27976-27-8)

9 alternate names

3 suppliers

3-(3,5-DIMETHYLPHENYL)PROPANOIC ACID (42287-87-6)

9 alternate names

3 suppliers

3-(3-Methylphenyl)propionic acid (3751-48-2)

9 alternate names

3 suppliers

Ethyl 2-oxo-4-phenylbutyrate (64920-29-2)

9 alternate names

3 suppliers

3-(4-Bromobenzoyl)propionic acid (6340-79-0)

9 alternate names

3 suppliers

3-(4-Fluorobenzoyl)propionic acid (366-77-8)

9 alternate names

3 suppliers

4-Benzoylbutyric acid (1501-05-9)

9 alternate names

3 suppliers

Methyl 3-phenylpropionate (103-25-3)

9 alternate names

3 suppliers

194146-02-6 (194146-02-6)

9 alternate names

3 suppliers

4-(4-Nitrophenyl)butyric acid (5600-62-4)

9 alternate names

3 suppliers

5-Benzoylpentanoic acid (4144-62-1)

9 alternate names

3 suppliers

1,3-Diphenylpropane (1081-75-0)

9 alternate names

3 suppliers

ISOBUTYLBENZENE (538-93-2)

9 alternate names

1 safety hazard

3 suppliers

4-Phenyl-1-butyne (16520-62-0)

9 alternate names

3 suppliers

3-Methyl-1-phenyl-2-butanone (2893-05-2)

9 alternate names

3 suppliers

1-(3-Methyl-3-butenyl)-4-methylbenzene (56818-01-0)

9 alternate names

3 suppliers

4-(2-Naphthyl)-4-oxobutanoic acid (1590-22-3)

9 alternate names

3 suppliers

(3-CHLOROPROPYL)BENZENE (104-52-9)

9 alternate names

3 suppliers

6-Benzoylhexanoic acid (7472-43-7)

9 alternate names

3 suppliers

8-Oxo-8-phenyloctanoic acid (24314-23-6)

9 alternate names

3 suppliers

BUTYROPHENONE (495-40-9)

9 alternate names

3 suppliers

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4-PHENYLBUTYRIC ACID

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