| Weight | 304.217 g/mol |
|---|---|
| Formula | C14H19Cl2NO2 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 9 |
chlorambucil (305-03-3)
Leukeran · CB 1348 · Lympholysin
Score:
#120 in Biochemistry
,
#521 in Biology
,
#551 in Chemistry
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- Fludarabine Compared with Chlorambucil as Primary Therapy for Chronic Lymphocytic Leukemia (The New England Journal of Medicine, 2000)
- Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions (The New England Journal of Medicine, 2014)
- Alemtuzumab Compared With Chlorambucil As First-Line Therapy for Chronic Lymphocytic Leukemia (Journal of Clinical Oncology, 2007)
- Rituximab Added to First-Line Mitoxantrone, Chlorambucil, and Prednisolone Chemotherapy Followed by Interferon Maintenance Prolongs Survival in Patients With Advanced Follicular Lymphoma: An East German Study Group Hematology and Oncology Study (Journal of Clinical Oncology, 2007)
- Increased Incidence of Acute Leukemia in Polycythemia Vera Associated with Chlorambucil Therapy (The New England Journal of Medicine, 1981)
- Chlorambucil in Indolent Chronic Lymphocytic Leukemia (The New England Journal of Medicine, 1998)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - H341: Suspected of causing genetic defects
Warning Germ cell mutagenicity - Category 2 - H360: May damage fertility or the unborn child
Danger Reproductive toxicity - Category 1A, 1B - H372: Causes damage to organs through prolonged or repeated exposure
Danger Specific target organ toxicity, repeated exposure - Category 1 - Leukeran
- CB 1348
- Lympholysin
- Chlorbutin
- N,N-Di-(2-chloroethyl)-p-aminophenylbutyric Acid
- CB1348
- Amboclorin
- CB-1348
- NSC 3088
- Chloraminophene
- NSC-3088
- NSC3088
- 4-(Bis(2-chloroethyl)amino)benzenebutanoic Acid
-
SMILESC1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl
-
InChIKeyJCKYGMPEJWAADB-UHFFFAOYSA-N
- Pubchem - chlorambucil
- Wikipedia - chlorambucil
Chlorambucil, sold under the brand name Leukeran among others, is a chemotherapy medication used to treat chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and non-Hodgkin lymphoma. For CLL it is a preferred treatment. It is given by mouth.
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Areas of Application
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Alternate Names
Estimated Properties
| Boiling Point | 352.95 C | EPA T.E.S.T. |
|---|---|---|
| Density | 1.28 g/cm3 | EPA T.E.S.T. |
| Flash Point | 246.21 C | EPA T.E.S.T. |
| Water Solubility | 335.87 mg/L | EPA T.E.S.T. |
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Synthesis
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chlorambucil
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