| Weight | 302.849 g/mol |
|---|---|
| Formula | C18H23ClN2 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 4 |
Desipramine hydrochloride (58-28-6)
Desipramine · Norpramin · Desmethylimipramine
Score:
#699 in Neuroscience
,
#3104 in Biology
,
#3880 in Chemistry
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- Effects of Desipramine, Amitriptyline, and Fluoxetine on Pain in Diabetic Neuropathy (The New England Journal of Medicine, 1992)
- Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders (Gastroenterology, 2003)
- A Double-Blind Comparison of Clomipramine and Desipramine in the Treatment of Trichotillomania (Hair Pulling) (The New England Journal of Medicine, 1989)
- Sympathetic nervous system activity in major depression. Basal and desipramine-induced alterations in plasma norepinephrine kinetics. (Archives of General Psychiatry, 1994)
- Desipramine Facilitation of Initial Cocaine Abstinence (Archives of General Psychiatry, 1989)
- Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test (Psychopharmacology, 1999)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Desipramine
- Norpramin
- Desmethylimipramine
- Pertofrane
- Pertofran
- Aventis Behring Brand of Desipramine Hydrochloride
- Petylyl
- Nu-Pharm Brand of Desipramine Hydrochloride
- Apotex Brand of Desipramine Hydrochloride
- Novopharm Brand of Desipramine Hydrochloride
- PMS-Desipramine
- Nu Pharm Brand of Desipramine Hydrochloride
- Pharmascience Brand of Desipramine Hydrochloride
- Pertrofran
- Ratiopharm Brand of Desipramine Hydrochloride
- Rhne-Poulenc Rorer Brand of Desipramine Hydrochloride
- Novo-Desipramine
- Temmler Brand of Desipramine Hydrochloride
- Demethylimipramine
- Rhne Poulenc Rorer Brand of Desipramine Hydrochloride
- Nu-Desipramine
- Novartis Brand of Desipramine Hydrochloride
- Aventis Brand of Desipramine Hydrochloride
- ratio-Desipramine
- Apo-Desipramine
-
SMILESCNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31.Cl
-
InChIKeyXAEWZDYWZHIUCT-UHFFFAOYSA-N
- Pubchem - Desipramine hydrochloride
- Wikipedia - desipramine hydrochloride
Desipramine, sold under the brand name Norpramin and Pertofrane among others, is a tricyclic antidepressant (TCA) which is used in the treatment of depression. It acts as a relatively selective norepinephrine reuptake inhibitor, though it does also have other activities such as weak serotonin reuptake inhibitory, 1-blocking, antihistamine, and anticholinergic effects. The drug is not considered a first-line treatment for depression since the introduction of selective serotonin reuptake inhibitor (SSRI) antidepressants, which have fewer side effects and are safer in overdose.
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