| Weight | 250.2 g/mol |
|---|---|
| Formula | C13H8F2O3 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 2 |
diflunisal (22494-42-4)
Dolobid · Dolocid · Novo-Diflunisal
Score:
#2158 in Biology
,
#2655 in Chemistry
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- Synthesis and biological activity of 4-thiazolidinones, thiosemicarbazides derived from diflunisal hydrazide (European Journal of Medicinal Chemistry, 2006)
- Repurposing diflunisal for familial amyloid polyneuropathy: A randomized clinical trial (JAMA, 2013)
- Diflunisal Analogues Stabilize the Native State of Transthyretin. Potent Inhibition of Amyloidogenesis. (Journal of Medicinal Chemistry, 2004)
- Synthesis and biological activities of diflunisal hydrazidehydrazones (European Journal of Medicinal Chemistry, 2003)
- Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis (Amyloid, 2006)
- Thermodynamics of solutions. II. Flurbiprofen and diflunisal as models for studying solvation of drug substances (European Journal of Pharmaceutical Sciences, 2003)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Dolobid
- Dolocid
- Novo-Diflunisal
- MK-647
- NovoDiflunisal
- Nu-Diflunisal
- Apo Diflunisal
- Novo Diflunisal
- MK647
- NuDiflunisal
- Dolobis
- Nu Diflunisal
- Apo-Diflunisal
- ApoDiflunisal
- MK 647
-
SMILESC1=CC(=C(C=C1C2=C(C=C(C=C2)F)F)C(=O)O)O
-
InChIKeyHUPFGZXOMWLGNK-UHFFFAOYSA-N
- Pubchem - diflunisal
- Wikipedia - diflunisal
Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. It was developed by Merck Sharp & Dohme in 1971, as MK647, after showing promise in a research project studying more potent chemical analogs of aspirin. It was first sold under the brand name Dolobid, marketed by Merck & Co., but generic versions are now widely available.
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diflunisal
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