| Weight | 405.969 g/mol |
|---|---|
| Formula | C26H28ClNO |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 9 |
Enclomiphene (15690-57-0, 911-45-5)
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- Serum concentrations of enclomiphene and zuclomiphene across consecutive cycles of clomiphene citrate therapy in anovulatory infertile women (Fertility and Sterility, 1999)
- DIFFERENTIAL RESPONSES OF ESTROGEN TARGET TISSUES IN RATS INCLUDING BONE TO CLOMIPHENE, ENCLOMIPHENE, AND ZUCLOMIPHENE (Endocrinology, 1998)
- Oral Enclomiphene Citrate Stimulates the Endogenous Production of Testosterone and Sperm Counts in Men with Low Testosterone: Comparison with Testosterone Gel (The Journal of Sexual Medicine, 2013)
- The effects of enclomiphene and zuclomiphene citrates on mouse embryos fertilized in vitro and in vivo (American Journal of Obstetrics and Gynecology, 1986)
- Estrogenic and antiestrogenic effects of enclomiphene and zuclomiphene on gonadotropin secretion by ovine pituitary cells in culture. (Endocrinology, 1983)
- Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement (BJUI, 2016)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3
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InChIKeyGKIRPKYJQBWNGO-UHFFFAOYSA-N
- Pubchem - Enclomiphene
- Wikipedia - enclomiphene
Enclomifene (INN) (tentative brand name Androxal), or enclomiphene (USAN), is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that is under development for the treatment of male hypogonadism. As of December 2016, it is in the pre-registration phase of development and is under review by the FDA in the United States and the EMA in Europe. Enclomifene acts by antagonizing the estrogen receptor (ER) in the pituitary gland, which reduces negative feedback by estrogen on the hypothalamic-pituitary-gonadal axis, thereby increasing gonadotropin secretion and hence gonadal production of testosterone.
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