| Weight | 382.33 g/mol |
|---|---|
| Formula | C15H28O7P2 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 11 |
farnesyl diphosphate (372-97-4, 13058-04-3)
Score:
#1138 in Biochemistry
,
#2893 in Biology
,
#3620 in Chemistry
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- Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates (Journal of Pharmacology and Experimental Therapeutics, 2001)
- Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. (Archives of Biochemistry and Biophysics, 2000)
- Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution. (Biochemistry, 1994)
- Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation (Plant Science, 2000)
- Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue. (Biochemistry, 1998)
- Yeast farnesyl-diphosphate synthase: site-directed mutagenesis of residues in highly conserved prenyltransferase domains I and II. (Proceedings of the National Academy of Sciences of the United States of America, 1994)
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Predict GHS Hazards for Any Chemical in silico.
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SMILESCC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C
-
InChIKeyVWFJDQUYCIWHTN-UHFFFAOYSA-N
- Pubchem - farnesyl diphosphate
- Wikipedia - farnesyl diphosphate
Farnesyl pyrophosphate (FPP), also known as farnesyl diphosphate (FDP), is an intermediate in both the mevalonate and non-mevalonate pathways used by organisms in the biosynthesis of terpenes, terpenoids, and sterols. It is used in the synthesis of CoQ (part of the electron transport chain), as well as being the immediate precursor of squalene (via the enzyme squalene synthase), dehydrodolichol diphosphate (a precursor of dolichol, which transports proteins to the ER lumen for N-glycosylation), and geranylgeranyl pyrophosphate (GGPP).
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farnesyl diphosphate
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