Weight | 254.171 g/mol |
---|---|
Formula | C10H5F3N4O |
Hydrogen Acceptors | 5 |
Hydrogen Donors | 1 |
Aromatic Rings | 1 |
Rotatable Bonds | 3 |
FCCP (370-86-5)
Carbonyl Cyanide para Trifluoromethoxyphenylhydrazone · (4-(Trifluoromethoxy)phenyl)hydrazonopropanedinitrile · Carbonyl Cyanide p Trifluoromethoxyphenylhydrazone
Score:
#89 in Molecular and cellular biology
,
#2508 in Biochemistry
,
#4896 in Biology
,
#6266 in Chemistry
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- An FCCP-sensitive Ca2+ store in bullfrog sympathetic neurons and its participation in stimulus-evoked changes in [Ca2+]i (The Journal of Neuroscience, 1994)
- The molecular mechanism of action of the proton ionophore FCCP (carbonylcyanide p-trifluoromethoxyphenylhydrazone) (Biophysical Journal, 1983)
- Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation (Cardiovascular Research, 2006)
- Monensin and FCCP inhibit the intracellular transport of alphavirus membrane glycoproteins. (Journal of Cell Biology, 1980)
- Bcl-2 protects against FCCP-induced apoptosis and mitochondrial membrane potential depolarization in PC12 cells. (Biochimica et Biophysica Acta, 1999)
- Effect of SH reagents on atractyloside binding to mitochondria and ADP translocation. Potentiation by ADP and its prevention by uncoupler FCCP (FEBS Letters, 1972)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Carbonyl Cyanide para Trifluoromethoxyphenylhydrazone
- (4-(Trifluoromethoxy)phenyl)hydrazonopropanedinitrile
- Carbonyl Cyanide p Trifluoromethoxyphenylhydrazone
- Carbonyl Cyanide para-Trifluoromethoxyphenylhydrazone
- Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone
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SMILESC1=CC(=CC=C1NN=C(C#N)C#N)OC(F)(F)F
-
InChIKeyBMZRVOVNUMQTIN-UHFFFAOYSA-N
- Pubchem - FCCP
- Wikipedia - carbonyl cyanide p-trifluoromethoxyphenylhydrazone
Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone (FCCP) is an ionophore that is a mobile ion carrier. It is referred to as an uncoupling agent because it disrupts ATP synthesis by transporting hydrogen ions through the mitochondrial membrane before they can be used to provide the energy for oxidative phosphorylation. It is a nitrile and hydrazone.
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Similar Compounds
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161290-85-3
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4-(difluoromethoxy)-2-methylaniline
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40750-71-8
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352-67-0
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p-Anisidine
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3 suppliers
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8 safety hazards
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(4-SEC-BUTOXYPHENYL)AMINE HYDROCHLORIDE
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(4469-80-1)
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(458-92-4)
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(6971-45-5)
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(1005-63-6)
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461-81-4
(461-81-4)
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(461-81-4)
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4-Methoxyphenyl isocyanate
(5416-93-3)
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(32459-62-4)
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(3460-49-9)
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68255-58-3
(68255-58-3)
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(33311-29-4)
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1208-86-2
(1208-86-2)
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(101-70-2)
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4-Methoxy-N-methylaniline
(5961-59-1)
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p-Hexadecyloxyaniline
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p-Decyloxyaniline
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(39905-45-8)
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4-Heptyloxyaniline
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