| Weight | 262.305 g/mol |
|---|---|
| Formula | C15H18O4 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 0 |
HELENALIN (6754-13-8)
Score:
#1499 in Biochemistry
,
#4395 in Chemistry
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- The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65 (Journal of Biological Chemistry, 1998)
- Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB. (Biological Chemistry, 1997)
- Antitumor agents. 21. A proposed mechanism for inhibition of cancer growth by tenulin and helenalin and related cyclopentenones. (Journal of Medicinal Chemistry, 1977)
- Helenanolide-type sesquiterpene lactonesIII. Rates and stereochemistry in the reaction of helenalin and related helenanolides with sulfhydryl containing biomolecules (Bioorganic & Medicinal Chemistry, 1997)
- Helenalin Triggers a CD95 Death Receptor-independent Apoptosis That Is Not Affected by Overexpression of Bcl-xL or Bcl-2 (Cancer Research, 2001)
- Constituents of Helenium Species. XIII. The Structure of Helenalin and Mexicanin A (Journal of the American Chemical Society, 1963)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1CC2C(C(C3(C1C=CC3=O)C)O)C(=C)C(=O)O2
-
InChIKeyZVLOPMNVFLSSAA-UHFFFAOYSA-N
- Pubchem - HELENALIN
- Wikipedia - helenalin
Helenalin is a sesquiterpene lactone found in Arnica montana and Arnica chamissonis foliosa. Helenalin is a highly toxic compound, with hepatic and lymphatic tissues particularly vulnerable to its effects. It is believed to be responsible for the toxicity and skin irritation associated with Arnica.
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