| Weight | 129.115 g/mol |
|---|---|
| Formula | C5H7NO3 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 1 |
L-Pyroglutamic acid (98-79-3)
Pyroglutamic Acid · Pyroglutamate · Pyrrolidonecarboxylic Acid
Score:
#520 in Neuroscience
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#905 in Biochemistry
,
#2404 in Biology
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#2986 in Chemistry
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- Sigma-Aldrich - L-Pyroglutamic acid25.20 - 338.10 USD
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- Glutaminyl cyclase inhibition attenuates pyroglutamate A and Alzheimer's diseaselike pathology (Nature Medicine, 2008)
- A technique for the removal of pyroglutamic acid from the amino terminus of proteins using calf liver pyroglutamate amino peptidase (Biochemical and Biophysical Research Communications, 1978)
- Pyroglutamatemodified amyloid peptides AN3(pE) strongly affect cultured neuron and astrocyte survival (Journal of Neurochemistry, 2002)
- Amyloid Protein Starting Pyroglutamate at Position 3 Is a Major Component of the Amyloid Deposits in the Alzheimer's Disease Brain (Biochemical and Biophysical Research Communications, 2000)
- Functional comparison of two human monocyte chemotactic protein-2 isoforms, role of the amino-terminal pyroglutamic acid and processing by CD26/dipeptidyl peptidase IV (Biochemistry, 1998)
- Intraneuronal pyroglutamate-Abeta 342 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model (Acta Neuropathologica, 2009)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Pyroglutamic Acid
- Pyroglutamate
- Pyrrolidonecarboxylic Acid
- 5-Oxoproline
- 5-Oxopyrrolidine-2-Carboxylic Acid
- Magnesium Pidolate
- Pidolic Acid
- 5-Ketoproline
-
SMILESC1CC(=O)NC1C(=O)O
-
InChIKeyODHCTXKNWHHXJC-UHFFFAOYSA-N
- Pubchem - L-Pyroglutamic acid
- Wikipedia - pyroglutamic acid
Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid, or pyroglutamate for its basic form) is a ubiquitous but little studied natural amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam. It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase. Pyroglutamate is found in many proteins including bacteriorhodopsin.
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L-Pyroglutamic acid
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