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memantine

Weight	179.307 g/mol
Formula	C₁₂H₂₁N
Hydrogen Acceptors	1
Hydrogen Donors	1
Aromatic Rings	0
Rotatable Bonds	0

memantine (19982-08-2)

Namenda · D 145 · D145

Score: #68 in Neurology , #348 in Neuroscience , #1591 in Biology

Adamantane · Amine · Antidementia agent · Antiparkinsonian agent · Bases (chemistry) · Cyclic compound · Cycloalkane · Drugs acting on the nervous system · Drugs by psychological effect · Pharmaceutical · Psychoactive drug · Psychoanaleptic

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Most-cited Publications

Memantine in Moderate-to-Severe Alzheimer's Disease (The New England Journal of Medicine, 2003)
Memantine treatment in Patients with moderate to Severe Alzheimer disease already receiving donepezil: A randomized controlled trial (JAMA, 2004)
Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonista review of preclinical data (Neuropharmacology, 1999)
Memantine for dementia (Cochrane Database of Systematic Reviews, 2006)
Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. (Nature Reviews Drug Discovery, 2006)
A Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine (Journal of Biological Chemistry, 2007)

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Alternate Names

Namenda
D 145
D145
Memantine Hydrochloride
1-Amino-3,5-dimethyladamantane
1,3-Dimethyl-5-aminoadamantane
Ebixa
D-145
Axura
Memantin
SMILES

CC12CC3CC(C1)(CC(C3)(C2)N)C
InChIKey

BUGYDGFZZOZRHP-UHFFFAOYSA-N

External Links

Pubchem - memantine
Wikipedia - memantine
Memantine is used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by blocking NMDA receptors. It was first synthesized by Eli Lilly and Company in 1968 as a potential agent to treat diabetes; the NMDA activity was discovered in the 1980s.

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CAS Directory

memantine (19982-08-2)

Namenda · D 145 · D145

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Most-cited Publications

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Alternate Names

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