| Weight | 215.768 g/mol |
|---|---|
| Formula | C12H22ClN |
| Hydrogen Acceptors | 1 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 0 |
MEMANTINE HYDROCHLORIDE (41100-52-1)
Memantine · Namenda · D 145
Score:
#106 in Neurology
,
#515 in Neuroscience
,
#2384 in Biology
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- Memantine in Moderate-to-Severe Alzheimer's Disease (The New England Journal of Medicine, 2003)
- Memantine treatment in Patients with moderate to Severe Alzheimer disease already receiving donepezil: A randomized controlled trial (JAMA, 2004)
- Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonista review of preclinical data (Neuropharmacology, 1999)
- Memantine for dementia (Cochrane Database of Systematic Reviews, 2006)
- A Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine (Journal of Biological Chemistry, 2007)
- Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity (The Journal of Neuroscience, 1992)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Memantine
- Namenda
- D 145
- D145
- 1-Amino-3,5-dimethyladamantane
- 1,3-Dimethyl-5-aminoadamantane
- Ebixa
- D-145
- Axura
- Memantin
-
SMILESCC12CC3CC(C1)(CC(C3)(C2)N)C.Cl
-
InChIKeyLDDHMLJTFXJGPI-UHFFFAOYSA-N
- Pubchem - MEMANTINE HYDROCHLORIDE
- Wikipedia - memantine hydrochloride
Memantine is used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by blocking NMDA receptors. It was first synthesized by Eli Lilly and Company in 1968 as a potential agent to treat diabetes; the NMDA activity was discovered in the 1980s.
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MEMANTINE HYDROCHLORIDE
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