Weight | 322.15 g/mol |
---|---|
Formula | C9H12N2O7P2 |
Hydrogen Acceptors | 5 |
Hydrogen Donors | 5 |
Aromatic Rings | 2 |
Rotatable Bonds | 4 |
Minodronic acid (180064-38-4)
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- TCI - Minodronic acid204.00 USD
- Minodronic acid (ONO-5920/YM529) prevents decrease in bone mineral density and bone strength, and improves bone microarchitecture in ovariectomized cynomolgus monkeys (Bone, 2008)
- Effect of minodronic acid (ONO-5920) on bone mineral density and arthritis in adult rats with collagen-induced arthritis. (Arthritis & Rheumatism, 2003)
- Nitrogen-containing bisphosphonate, YM529/ONO-5920 (a novel minodronic acid), inhibits RANKL expression in a cultured bone marrow stromal cell line ST2 (Biochemical and Biophysical Research Communications, 2005)
- A Third-Generation Bisphosphonate, Minodronic Acid (YM529), Augments the Interferon /-Mediated Inhibition of Renal Cell Cancer Cell Growth Both In vitro and In vivo (Clinical Cancer Research, 2005)
- Minodronic acid, a third-generation bisphosphonate, antagonizes purinergic P2X2/3 receptor function and exerts an analgesic effect in pain models (European Journal of Pharmacology, 2008)
- A third-generation bisphosphonate, minodronic acid (YM529), successfully prevented the growth of bladder cancer in vitro and in vivo (British Journal of Cancer, 2006)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1=CC2=NC=C(N2C=C1)CC(O)(P(=O)(O)O)P(=O)(O)O
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InChIKeyVMMKGHQPQIEGSQ-UHFFFAOYSA-N
- Pubchem - Minodronic acid
- Wikipedia - minodronic acid
Minodronic acid is a third-generation bisphosphonate drug. It is approved for use in Japan for the treatment of osteoporosis. Its mechanism of action involves inhibition of farnesyl pyrophosphate synthase activity.
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