| Weight | 457.914 g/mol |
|---|---|
| Formula | C23H24ClN3O5 |
| Hydrogen Acceptors | 8 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 3 |
TOPOTECAN HYDROCHLORIDE (119413-54-6)
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- Topotecan, pegylated liposomal doxorubicin hydrochloride and paclitaxel for second-line or subsequent treatment of advanced ovarian cancer: a systematic review and economic evaluation (Health Technology Assessment, 2006)
- A study of variable hydration states in topotecan hydrochloride (Journal of Pharmaceutical and Biomedical Analysis, 2006)
- Cost-minimisation analysis of pegylated liposomal doxorubicin hydrochloride versus topotecan in the treatment of patients with recurrent epithelial ovarian cancer in Spain (British Journal of Cancer, 2003)
- Involvement of Rat and Human Organic Anion Transporter 3 in the Renal Tubular Secretion of Topotecan [(S)-9-Dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride] (Journal of Pharmacology and Experimental Therapeutics, 2007)
- Stability and compatibility of topotecan hydrochloride for injection with common infusion solutions and containers (Journal of Pharmaceutical and Biomedical Analysis, 1997)
- Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for advanced recurrent or refractory ovarian cancer: a systematic review and economic evaluation (Health Technology Assessment, 2015)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=C(C5=C4)CN(C)C)O)O.Cl
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InChIKeyDGHHQBMTXTWTJV-UHFFFAOYSA-N
- Pubchem - TOPOTECAN HYDROCHLORIDE
- Wikipedia - topotecan hydrochloride
Topotecan (trade name Hycamtin) is a chemotherapeutic agent that is a topoisomerase inhibitor. It is a synthetic, water-soluble analog of the natural chemical compound camptothecin. It is used in the form of its hydrochloride salt to treat ovarian cancer, lung cancer and other cancer types.
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