| Weight | 515.617 g/mol |
|---|---|
| Formula | C32H29N5O2 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 5 |
| Rotatable Bonds | 5 |
Enzastaurin (170364-57-5)
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- The Protein Kinase CSelective Inhibitor, Enzastaurin (LY317615.HCl), Suppresses Signaling through the AKT Pathway, Induces Apoptosis, and Suppresses Growth of Human Colon Cancer and Glioblastoma Xenografts (Cancer Research, 2005)
- Phase III Study of Enzastaurin Compared With Lomustine in the Treatment of Recurrent Intracranial Glioblastoma (Journal of Clinical Oncology, 2010)
- Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma. (Journal of Clinical Oncology, 2007)
- Phase I Dose Escalation and Pharmacokinetic Study of Enzastaurin, an Oral Protein Kinase C Beta Inhibitor, in Patients With Advanced Cancer (Journal of Clinical Oncology, 2006)
- Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl) (Blood, 2007)
- Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrm macroglobulinemia (Blood, 2007)
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Predict GHS Hazards for Any Chemical in silico.
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SMILESCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)C6CCN(CC6)CC7=CC=CC=N7
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InChIKeyAXRCEOKUDYDWLF-UHFFFAOYSA-N
- Pubchem - Enzastaurin
- Wikipedia - enzastaurin
Enzastaurin is a synthetic bisindolylmaleimide with potential antineoplastic activity. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply, preventing growth.
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Enzastaurin
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