| Weight | 605.637 g/mol |
|---|---|
| Formula | C27H27N9O6S |
| Hydrogen Acceptors | 13 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 5 |
| Rotatable Bonds | 12 |
Tezosentan (180384-57-0)
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- Effects of tezosentan on symptoms and clinical outcomes in patients with acute heart failure: the VERITAS randomized controlled trials. (JAMA, 2007)
- Pharmacology of Tezosentan, New Endothelin Receptor Antagonist Designed for Parenteral Use (Journal of Pharmacology and Experimental Therapeutics, 1999)
- Tezosentan in patients with acute heart failure and acute coronary syndromes: Results of the randomized intravenous tezosentan study (RITZ-4) (Journal of the American College of Cardiology, 2003)
- RITZ-5: randomized intravenous TeZosentan (an endothelin-A/B antagonist) for the treatment of pulmonary edema. A prospective, multicenter, double-blind, placebo-controlled study (Journal of the American College of Cardiology, 2002)
- Hemodynamic and clinical effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients hospitalized for acute decompensated heart failure (Journal of the American College of Cardiology, 2003)
- Hemodynamic Effects of Tezosentan, an Intravenous Dual Endothelin Receptor Antagonist, in Patients With Class III to IV Congestive Heart Failure (Circulation, 2001)
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Predict GHS Hazards for Any Chemical in silico.
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SMILESCC(C)C1=CN=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=CC(=NC=C3)C4=NNN=N4)OCCO)OC5=CC=CC=C5OC
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- Pubchem - Tezosentan
- Wikipedia - tezosentan
Tezosentan is a non-selective ETA and ETB receptor antagonist. It acts as a vasodilator and was designed as a therapy for patients with acute heart failure. Recent studies have shown however, that tezosentan does not improve dyspnea or reduce the risk of fatal or nonfatal cardiovascular events.
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Tezosentan
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