| Weight | 1085.156 g/mol |
|---|---|
| Formula | C52H76O24 |
| Hydrogen Acceptors | 24 |
| Hydrogen Donors | 11 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 15 |
MITHRAMYCIN (97666-60-9, 18378-89-7)
Score:
#444 in Biochemistry
,
#1459 in Biology
,
#1711 in Chemistry
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- Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo. (Journal of Clinical Investigation, 1991)
- Physicochemical properties of complexes between deoxyribonucleic acid and antibiotics which affect ribonucleic acid synthesis (actinomycin, daunomycin, cinerubin, nogalamycin, chormomycin, mithramycin, and olivomycin). (Biochemistry, 1966)
- Mithramycin- and 4'-6-diamidino-2-phenylindole (DAPI)-DNA staining for fluorescence microspectrophotometric measurement of DNA in nuclei, plastids, and virus particles. (Journal of Histochemistry and Cytochemistry, 1981)
- Chromomycin, mithramycin, and olivomycin binding sites on heterogeneous deoxyribonucleic acid. Footprinting with (methidiumpropyl-EDTA)iron(II). (Biochemistry, 1983)
- Applications of Fluorochromes to Pollen Biology. I. Mithramycin and 4,6-Diamidino-2-Phenylindole (Dapi) as Vital Stains and for Quantitation of Nuclear Dna (Biotechnic & Histochemistry, 1985)
- Chemotherapy for the Brain: The Antitumor Antibiotic Mithramycin Prolongs Survival in a Mouse Model of Huntington's Disease (The Journal of Neuroscience, 2004)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1C(C(CC(O1)OC2CC(OC(C2O)C)OC3=CC4=CC5=C(C(=O)C(C(C5)C(C(=O)C(C(C)O)O)OC)OC6CC(C(C(O6)C)O)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O
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InChIKeyCFCUWKMKBJTWLW-UHFFFAOYSA-N
- Pubchem - MITHRAMYCIN
- Wikipedia - Plicamycin
Plicamycin (INN, also known as mithramycin; trade name Mithracin) is an antineoplastic antibiotic produced by Streptomyces plicatus. It is an RNA synthesis inhibitor. The manufacturer discontinued production in 2000.
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