| Weight | 147.13 g/mol |
|---|---|
| Formula | C5H9NO4 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 4 |
N-methyl-D-aspartic acid (6384-92-5)
Score:
#798 in Neuroscience
,
#3500 in Biology
,
#4377 in Chemistry
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- The induction and maintenance of central sensitization is dependent on N-methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states (Pain, 1991)
- N-methyl-D-aspartic acid receptor structure and function (Physiological Reviews, 1994)
- Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones. (The Journal of Physiology, 1987)
- A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists. (Journal of Neurochemistry, 1989)
- PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. (Journal of Biological Chemistry, 1999)
- Relief of post-herpetic neuralgia with the N-methyl-D-aspartic acid receptor antagonist ketamine: a double-blind, cross-over comparison with morphine and placebo. (Pain, 1994)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCNC(CC(=O)O)C(=O)O
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InChIKeyHOKKHZGPKSLGJE-UHFFFAOYSA-N
- Pubchem - N-methyl-D-aspartic acid
- Wikipedia - N-methyl-D-aspartic acid
N-Methyl-D-aspartic acid or N-Methyl-D-aspartate (NMDA) is an amino acid derivative that acts as a specific agonist at the NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Unlike glutamate, NMDA only binds to and regulates the NMDA receptor and has no effect on other glutamate receptors (such as those for AMPA and kainate). NMDA receptors are particularly important when they become overactive during withdrawal from alcohol as this causes symptoms such as agitation and, sometimes, epileptiform seizures.
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N-methyl-D-aspartic acid
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