| Weight | 436.465 g/mol |
|---|---|
| Formula | C21H21N2NaO5S |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 5 |
NAFCILLIN SODIUM (985-16-0)
Nafcillin · Nafcil · Sodium Nafcillin
Score:
#418 in Microbiology
,
#3367 in Biology
,
#4190 in Chemistry
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- Impact of High-Inoculum Staphylococcus aureus on the Activities of Nafcillin, Vancomycin, Linezolid, and Daptomycin, Alone and in Combination with Gentamicin, in an In Vitro Pharmacodynamic Model (Antimicrobial Agents and Chemotherapy, 2004)
- Comparative effectiveness of nafcillin or cefazolin versus vancomycin in methicillin-susceptible Staphylococcus aureus bacteremia (BMC Infectious Diseases, 2011)
- Nafcillin-gentamicin synergism in experimental staphylococcal endocarditis. (Journal of Laboratory and Clinical Medicine, 1976)
- Increased amounts of a novel penicillin-binding protein in a strain of methicillin-resistant Staphylococcus aureus exposed to nafcillin. (Journal of Clinical Investigation, 1985)
- Suspected nafcillin-induced interstitial nephritis. (Annals of Pharmacotherapy, 1993)
- Cefotaxime Compared with Nafcillin Plus Tobramycin for Serious Bacterial Infections: A Randomized, Double-Blind Trial (Annals of Internal Medicine, 1984)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Nafcillin
- Nafcil
- Sodium Nafcillin
- Nafcillin, Monosodium Salt, Anhydrous
- Naphthamidopenicillin
-
SMILESCCOC1=C(C2=CC=CC=C2C=C1)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].[Na+]
-
InChIKeyAYAPZOUDXCDGIF-UHFFFAOYSA-M
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Synthesis
2-Ethoxy-1-naphthoyl Chloride
+
(2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
(Schotten-Baumann amide from acid)
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