| Weight | 310.393 g/mol |
|---|---|
| Formula | C20H22O3 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 4 |
Nafenopin (3771-19-5)
Score:
#58 in Molecular and cellular biology
,
#1783 in Biochemistry
,
#4914 in Chemistry
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- Enhanced Proliferation of Putative Preneoplastic Cells in Rat Liver following Treatment with the Tumor Promoters Phenobarbital, Hexachlorocyclohexane, Steroid Compounds, and Nafenopin (Cancer Research, 1981)
- Suppression of Liver Cell Apoptosis In Vitro by the Non-Genotoxic Hepatocarcinogen and Peroxisome Proliferator Nafenopin (Journal of Cell Biology, 1994)
- Hepatocellular carcinomas in acatalasemic mice treated with nafenopin, a hypolipidemic peroxisome proliferator. (Cancer Research, 1976)
- Malignant Tumors in Rats Fed Nafenopin, a Hepatic Peroxisome Proliferator (Journal of the National Cancer Institute, 1977)
- The hepatic effects of hypolipidemic drugs (clofibrate, nafenopin, tibric acid, and Wy-14,643) on hepatic peroxisomes and peroxisome-associated enzymes. (American Journal of Pathology, 1978)
- Comparative studies on nafenopin-induced hepatic peroxisome proliferation in the rat, Syrian hamster, guinea pig, and marmoset (Toxicology and Applied Pharmacology, 1989)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(C)(C(=O)O)OC1=CC=C(C=C1)C2CCCC3=CC=CC=C23
-
InChIKeyXJGBDJOMWKAZJS-UHFFFAOYSA-N
- Pubchem - Nafenopin
- Wikipedia - nafenopin
Nafenopin is a hypolipidemic agent.
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Synthesis
2-methyl-2-phenoxypropanoic acid
+
1-chloro-1,2,3,4-tetrahydronaphthalene
(Friedel-Crafts alkylation)
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