| Weight | 298.346 g/mol |
|---|---|
| Formula | C16H18N4O2 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 7 |
Nialamide (51-12-7)
Score:
#122 in Neurology
,
#558 in Neuroscience
,
#2513 in Biology
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- Effects of antagonists upon locomotor stimulation induced by injection of dopamine and Noradrenaline into the nucleus accumbens of nialamide-pretreated rats. (Psychopharmacology, 1975)
- Effects of apomorphine, (+)-amphetamine, and nialamide on tetrabenazine-induced suppression of sexual behavior in the male rat (European Journal of Pharmacology, 1969)
- Subsensitivity of the Beta-Adrenergic Receptor-Linked Adenylate Cyclase System of Rat Pineal Gland following Repeated Treatment with Desmethylimipramine and Nialamide (Molecular Pharmacology, 1981)
- On the role of central nervous system catecholamines and 5-hydroxytryptamine in the nialamide-induced behavioural syndrome (British Journal of Pharmacology, 1972)
- Potentiating effect of lithium chloride on aggressive behaviour induced in mice by nialamide plus L-DOPA and by clonidine (European Journal of Pharmacology, 1975)
- Serotonin and nialamide differentially regulate survival and growth of cultured serotonin and catecholamine neurons (Developmental Brain Research, 1991)
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SMILESC1=CC=C(C=C1)CNC(=O)CCNNC(=O)C2=CC=NC=C2
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InChIKeyNOIIUHRQUVNIDD-UHFFFAOYSA-N
- Pubchem - Nialamide
- Wikipedia - nialamide
Nialamide (Niamid, Niamide, Nuredal, Surgex) is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant. It was withdrawn by Pfizer several decades ago due to the risk of hepatotoxicity. The antiatherogenic activity of nialamide was used to design pyridinolcarbamate.
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Synthesis
Reactant
+
Benzylamine
(Schotten-Baumann amide from acid)
benzaldehyde
+
Reactant
(Reductive amination)
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Nialamide
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