| Weight | 805.015 g/mol |
|---|---|
| Formula | C44H68O13 |
| Hydrogen Acceptors | 12 |
| Hydrogen Donors | 5 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 10 |
okadaic acid (78111-17-8)
Ocadaic Acid
Score:
#803 in Biochemistry
,
#2176 in Biology
,
#2678 in Chemistry
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- Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics (Biochemical Journal, 1988)
- Okadaic acid: a new probe for the study of cellular regulation (Trends in Biochemical Sciences, 1990)
- Calyculin A and okadaic acid: Inhibitors of protein phosphatase activity (Biochemical and Biophysical Research Communications, 1989)
- Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism (Nature, 1989)
- Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria (Journal of the American Chemical Society, 1981)
- Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter. (Proceedings of the National Academy of Sciences of the United States of America, 1988)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Ocadaic Acid
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SMILESCC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)O)O)O)C)O)O
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InChIKeyQNDVLZJODHBUFM-UHFFFAOYSA-N
- Pubchem - okadaic acid
- Wikipedia - okadaic acid
Okadaic acid, C44H68O13, is a toxin produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. One of the primary causes of diarrhetic shellfish poisoning, okadaic acid is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells. A polyketide, polyether derivative of a C38 fatty acid, okadaic acid and other members of its family have shined light upon many biological processes both with respect to dinoflagellete polyketide synthesis as well as the role of protein phosphatases in cell growth.
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