| Weight | 650.762 g/mol |
|---|---|
| Formula | C34H50O12 |
| Hydrogen Acceptors | 12 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 13 |
thapsigargin (67526-95-8)
Score:
#64 in Molecular and cellular biology
,
#1934 in Biochemistry
,
#4111 in Biology
,
#5177 in Chemistry
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- Sigma-Aldrich - thapsigargin86.60 - 919.00 USD
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- Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase (Proceedings of the National Academy of Sciences of the United States of America, 1990)
- Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps. (Journal of Biological Chemistry, 1991)
- Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane. (Journal of Biological Chemistry, 1989)
- A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases (Trends in Pharmacological Sciences, 1998)
- Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage. (Inflammation Research, 1989)
- Inhibition of the sarcoplasmic reticulum Ca2+ transport ATPase by thapsigargin at subnanomolar concentrations. (Journal of Biological Chemistry, 1991)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCCCCCCC(=O)OC1C2C(=C(C1OC(=O)C(=CC)C)C)C3C(C(CC2(C)OC(=O)C)OC(=O)CCC)(C(C(=O)O3)(C)O)O
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InChIKeyIXFPJGBNCFXKPI-UHFFFAOYSA-N
- Pubchem - thapsigargin
- Wikipedia - thapsigargin
Thapsigargin is non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). Structurally, thapsigargin is classified as a sesquiterpene lactone, and is extracted from a plant, Thapsia garganica. It is a tumor promoter in mammalian cells.
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thapsigargin
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