| Weight | 450.619 g/mol |
|---|---|
| Formula | C29H38O4 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 1 |
celastrol (34157-83-0)
Score:
#1649 in Biochemistry
,
#3726 in Biology
,
#4690 in Chemistry
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- Sigma-Aldrich - Search for celastrol
- Fisher Scientific - Search for celastrol
- TCI - celastrol270.00 USD
- Celastrol, a Triterpene Extracted from the Chinese Thunder of God Vine, Is a Potent Proteasome Inhibitor and Suppresses Human Prostate Cancer Growth in Nude Mice (Cancer Research, 2006)
- Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease (Progress in Neuro-psychopharmacology & Biological Psychiatry, 2001)
- Celastrol, a Novel Triterpene, Potentiates TNF-Induced Apoptosis and Suppresses Invasion of Tumor Cells by Inhibiting NF-B-Regulated Gene Products and TAK1-Mediated NF-B Activation (Blood, 2006)
- Inhibition of NF-B activation through targeting IB kinase by celastrol, a quinone methide triterpenoid (Biochemical Pharmacology, 2006)
- Celastrol: Molecular targets of Thunder God Vine. (Biochemical and Biophysical Research Communications, 2010)
- Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-targeted Molecule (Molecular Biology of the Cell, 2007)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O
-
InChIKeyKQJSQWZMSAGSHN-UHFFFAOYSA-N
- Pubchem - celastrol
- Wikipedia - celastrol
Celastrol (tripterine) is a chemical compound isolated from the root extracts of Tripterygium wilfordii (Thunder god vine) and Celastrus regelii. Celastrol is a pentacyclic triterpenoid and belongs to the family of quinone methides. In in vitro and in vivo animal experiments, celastrol exhibits antioxidant, anti-inflammatory, anticancer, and insecticidal activities.
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celastrol
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