Score: #480 in Microbiology , #1709 in Biochemistry , #3801 in Biology , #4783 in Chemistry

  Anti-inflammatory agent · Anti-inflammatory and antirheumatic product · Antineoplastic and immunomodulating drug · Drugs acting on the musculoskeletal system · Glucocorticoid · Hormonal agent · Immunomodulating drug · Immunosuppressant · Mineralocorticoid · Systemic hormonal preparation

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Suppliers

• Sigma-Aldrich - Cortexolone
  41.90 - 102.00 USD
• Fisher Scientific - Search for Cortexolone
• TCI - Cortexolone
  59.00 USD

Most-cited Publications

• Glucocorticoid Receptors in Rat Thymocytes INTERACTIONS WITH THE ANTIGLUCOCORTICOID CORTEXOLONE AND MECHANISM OF ITS ACTION (Journal of Biological Chemistry, 1974)
• 11-Hydroxylation of Cortexolone (Reichstein Compound S) to Hydrocortisone by Curvularia lunata Entrapped in Photo-Cross-Linked Resin Gels (Applied and Environmental Microbiology, 1983)
• Cortexolone: Binding to glucocorticoid receptors in rat thymocytes and mechanism of its antiglucocorticoid action (Biochemical and Biophysical Research Communications, 1972)
• Reference levels for 17-hydroxyprogesterone, 11-desoxycortisol, cortisol, testosterone, dehydroepiandrosterone sulfate and androstenedione in infants from birth to six months of age. (European Journal of Pediatrics, 2008)
• Sequential conversion of cortexolone to prednisolone by immobilized mycelia of Curvularia lunata and immobilized cells of Arthrobacter simplex (Applied Microbiology and Biotechnology, 1985)
• THE INDEPENDENT ESTIMATION OF 11-DESOXYCORTISOL AND CORTISOL IN A SINGLE PLASMA SAMPLE* (The Journal of Clinical Endocrinology and Metabolism, 1961)

Areas of Application

Safety

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Trends

Alternate Names

• Reichstein's Substance S
• 11 Desoxycortisol
• Cortodoxone
• 11-Desoxycortisone
• 11 Desoxycortisone
• Reichsteins Substance S
• 11-Deoxycortisol
• Reichstein Substance S
• 11 Deoxycortisol
• 11-Desoxycortisol
• SMILES
  CC12CCC(=O)C=C1CCC3C2CCC4(C3CCC4(C(=O)CO)O)C
• InChIKey
  WHBHBVVOGNECLV-UHFFFAOYSA-N

External Links

• Pubchem - Cortexolone
• Wikipedia - cortodoxone
  11-Deoxycortisol, also known as cortodoxone (INN) or cortexolone, as well as 17,21-dihydroxyprogesterone or 17,21-dihydroxypregn-4-ene-3,20-dione, is a glucocorticoid steroid hormone. It was first synthesized by Tadeusz Reichstein, and has also been referred to as Reichstein's Substance. On April 5, 1952, biochemist Durey Peterson and microbiologist Herbert Murray at Upjohn published the first report of a breakthrough fermentation process for the microbial 11-oxygenation of steroids (e.g.

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