| Weight | 281.352 g/mol |
|---|---|
| Formula | C15H23NO4 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 3 |
cycloheximide (66-81-9)
Actidione · Cicloheximide
Score:
#638 in Biochemistry
,
#1816 in Biology
,
#2170 in Chemistry
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- Sigma-Aldrich - cycloheximide54.40 - 407.00 USD
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- NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. (Molecular and Cellular Biology, 2001)
- FLAGELLAR ELONGATION AND SHORTENING IN CHLAMYDOMONAS : The Use of Cycloheximide and Colchicine to Study the Synthesis and Assembly of Flagellar Proteins (Journal of Cell Biology, 1969)
- The Mechanism by which Cycloheximide and Related Glutarimide Antibiotics Inhibit Peptide Synthesis on Reticulocyte Ribosomes (Journal of Biological Chemistry, 1971)
- Cultivation of Chlamydia trachomatis in cycloheximide-treated mccoy cells. (Journal of Clinical Microbiology, 1977)
- Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin (Nature Chemical Biology, 2010)
- Cycloheximide: Aspects of Inhibition of Protein Synthesis in Mammalian Cells (Science, 1964)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - H300: Fatal if swallowed
Danger Acute toxicity, oral - Category 1, 2 - H319: Causes serious eye irritation
Warning Serious eye damage/eye irritation - Category 2A - H360: May damage fertility or the unborn child
Danger Reproductive toxicity - Category 1A, 1B - H411: Toxic to aquatic life with long lasting effects
Hazardous to the aquatic environment, long-term hazard - Category 2 - Actidione
- Cicloheximide
-
SMILESCC1CC(C(=O)C(C1)C(CC2CC(=O)NC(=O)C2)O)C
-
InChIKeyYPHMISFOHDHNIV-UHFFFAOYSA-N
- Pubchem - cycloheximide
- Wikipedia - cycloheximide
Cycloheximide is a eukaryote protein synthesis inhibitor, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis (movement of two tRNA molecules and mRNA in relation to the ribosome), thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells studied in vitro (i.e.
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cycloheximide
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