| Weight | 402.663 g/mol |
|---|---|
| Formula | C27H46O2 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 6 |
27-hydroxycholesterol (20380-11-4)
Score:
#647 in Neuroscience
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#1135 in Biochemistry
,
#2888 in Biology
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#3615 in Chemistry
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- 27-Hydroxycholesterol Is an Endogenous Ligand for Liver X Receptor in Cholesterol-loaded Cells (Journal of Biological Chemistry, 2001)
- 27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology (Science, 2013)
- 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen (Nature Medicine, 2007)
- Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain (Journal of Lipid Research, 2005)
- Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on -amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells (Molecular Neurodegeneration, 2009)
- 27-Hydroxycholesterol Is an Endogenous Selective Estrogen Receptor Modulator (Molecular Endocrinology, 2008)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)CO
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InChIKeyFYHRJWMENCALJY-UHFFFAOYSA-N
- Pubchem - 27-hydroxycholesterol
- Wikipedia - (25R)-cholest-5-ene-3,26-diol
27-Hydroxycholesterol (27-HC) is an endogenous oxysterol with multiple biological functions, including activity as a selective estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR). It is a metabolite of cholesterol that is produced by the enzyme CYP27A1. A link between high cholesterol and breast cancer has been identified, and it has been proposed that this is due to 27-HC production by CYP27A1.
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