| Weight | 402.663 g/mol |
|---|---|
| Formula | C27H46O2 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 5 |
22R-hydroxycholesterol (22348-64-7, 17954-98-2)
"What do you need help with?"
LabBot
- Sigma-Aldrich - Search for 22R-hydroxycholesterol
- Fisher Scientific - Search for 22R-hydroxycholesterol
- TCI - Search for 22R-hydroxycholesterol
- 22R-Hydroxycholesterol and 9-cis-Retinoic Acid Induce ATP-binding Cassette Transporter A1 Expression and Cholesterol Efflux in Brain Cells and Decrease Amyloid Secretion (Journal of Biological Chemistry, 2003)
- Mass spectrometric study of the enzymatic conversion of cholesterol to (22R)-22-hydroxycholesterol, (20R,22R)-20,22-dihydroxycholesterol, and pregnenolone, and of (22R)-22-hydroxycholesterol to the lgycol and pregnenolone in bovine adrenocortical preparations. Mode of oxygen incorporation. (Journal of Biological Chemistry, 1975)
- 22R-Hydroxycholesterol protects neuronal cells from -amyloid-induced cytotoxicity by binding to -amyloid peptide (Journal of Neurochemistry, 2002)
- Transformation of labeled cholesterol, 20-hydroxycholesterol, (22R)-22-hydroxycholesterol, and (22R)-20,22-dihydroxycholesterol by adrenal acetone-dried preparations from guinea pigs, cattle and man: I. Establishment of radiochemical purity of products (Steroids, 1970)
- The isolation of crystalline 22R-hydroxycholesterol and 20,22R-dihydroxycholesterol from bovine adrenals (Biochemical and Biophysical Research Communications, 1970)
- Transformation of labeled cholesterol, 20-hydroxycholesterol, (22R)-22-hydroxycholesterol, and (22R)-20, 22-dihydroxycholesterol by adrenal acetone-dried preparations from Guinea pigs, cattle and man: II. Kinetic studies (Steroids, 1970)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(C)CCC(C(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)O
-
InChIKeyRZPAXNJLEKLXNO-UHFFFAOYSA-N
- Pubchem - 22R-hydroxycholesterol
- Wikipedia - 22R-Hydroxycholesterol
22R-Hydroxycholesterol, or (3)-cholest-5-ene-3,22-diol is an endogenous, metabolic intermediate in the biosynthesis of the steroid hormones from cholesterol. Cholesterol ((3)-cholest-5-en-3-ol) is hydroxylated by cholesterol side-chain cleavage enzyme (P450scc) to form 22R-hydroxycholesterol, which is subsequently hydroxlated again by P450scc to form 20,22R-dihydroxycholesterol, and finally the bond between carbons 20 and 22 is cleaved by P450scc to form pregnenolone ((3)-3-hydroxypregn-5-en-20-one), the precursor to the steroid hormones. It is an agonist of the liver X receptor.
Suppliers
Most-cited Publications
Areas of Application
Safety
Alternate Names
External Links
Similar Compounds
Cerebrosterol
(474-73-7)
1 alternate name
3 suppliers
27-hydroxycholesterol
(20380-11-4)
1 alternate name
3 suppliers
7-Dehydrocholesterol
(434-16-2)
1 alternate name
3 suppliers
Dihydrocholesterol
(80-97-7)
1 alternate name
3 suppliers
Lathosterol
(80-99-9)
1 alternate name
3 suppliers
DESMOSTEROL
(313-04-2)
1 alternate name
3 suppliers
Zymostenol
(566-97-2)
1 alternate name
3 suppliers
Zymosterol
(128-33-6)
1 alternate name
3 suppliers
STIGMASTEROL
(83-48-7)
1 alternate name
3 suppliers
LITHOCHOLIC ACID
(434-13-9)
1 alternate name
3 suppliers
BETA-SITOSTEROL
(68555-08-8, 19044-06-5, 83-46-5)
1 alternate name
3 suppliers
Isolithocholic acid
(1534-35-6)
1 alternate name
3 suppliers
17-Hydroxypregnenolone
(387-79-1)
1 alternate name
3 suppliers
4,4-Dimechol-8,14,24-trienol
(64284-64-6)
1 alternate name
3 suppliers
Glycolithocholic acid
(474-74-8)
1 alternate name
3 suppliers
4-Cholesten-3-one
(601-57-0)
1 alternate name
3 suppliers
7-Ketodeoxycholic acid
(911-40-0)
1 alternate name
3 suppliers
Coprocholic acid
(547-98-8)
1 alternate name
3 suppliers
3,7-Dihydroxy-12-oxocholanoic acid
(2458-08-4)
1 alternate name
3 suppliers
7alpha-Hydroxy-4-cholesten-3-one
(3862-25-7)
1 alternate name
3 suppliers
estradiol valerate
(979-32-8)
1 alternate name
3 suppliers
Glycocholic acid
(475-31-0)
1 alternate name
3 suppliers
21-Hydroxypregnenolone
(1164-98-3)
1 alternate name
3 suppliers
53-00-9
(53-00-9)
1 alternate name
3 suppliers
testosterone enanthate
(315-37-7)
1 alternate name
3 suppliers
Deoxycorticosterone acetate
(56-47-3)
1 alternate name
3 suppliers
hydrocortisone acetate
(50-03-3)
1 alternate name
3 suppliers
Testosterone undecanoate
(5949-44-0)
1 alternate name
3 suppliers
CAS Directory
