| Weight | 504.62 g/mol |
|---|---|
| Formula | C28H40O8 |
| Hydrogen Acceptors | 8 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 7 |
Phorbol 12,13-dibutyrate (61557-88-8, 37558-16-0)
Score:
#841 in Neuroscience
,
#1629 in Biochemistry
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#3696 in Biology
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#4650 in Chemistry
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- Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C (The Journal of Neuroscience, 1995)
- Protein kinase C activity in the rat hippocampus after forebrain ischemia: autoradiographic analysis by [3H]phorbol 12,13-dibutyrate (Brain Research, 1989)
- Highly Lipophilic Phorbol Esters as Inhibitors of Specific [3H]Phorbol 12,13-Dibutyrate Binding (Cancer Research, 1985)
- Down regulation of specific binding of [20-3H]phorbol 12,13-dibutyrate and phorbol ester-induced differentiation of human promyelocytic leukemia cells. (Proceedings of the National Academy of Sciences of the United States of America, 1981)
- Characterization of Specific Binding of [3H]Phorbol 12,13-Dibutyrate and [3H]Phorbol 12-Myristate 13-Acetate to Mouse Brain (Cancer Research, 1980)
- Calcium dependence of phorbol 12,13-dibutyrate-induced force and myosin light chain phosphorylation in arterial smooth muscle. (Journal of Pharmacology and Experimental Therapeutics, 1987)
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Predict GHS Hazards for Any Chemical in silico.
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SMILESCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)CCC)O)C
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InChIKeyBQJRUJTZSGYBEZ-UHFFFAOYSA-N
- Pubchem - Phorbol 12,13-dibutyrate
- Wikipedia - phorbol 12,13-dibutyrate
Phorbol 12,13-dibutyrate (PDBu) is a phorbol ester which is one of the constituents of croton oil. As an activator of protein kinase C, it is a weak tumor promoter compared to 12-O-tetradecanoylphorbol-13-acetate. PDBu is widely used as a chemical reagent because of its solubility in water and other organic solvents.
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