| Weight | 364.438 g/mol |
|---|---|
| Formula | C20H28O6 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 5 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 1 |
PHORBOL (17673-25-5)
Score:
#23 in Molecular and cellular biology
,
#755 in Biochemistry
,
#2084 in Biology
,
#2557 in Chemistry
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- Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. (Journal of Biological Chemistry, 1982)
- Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor (Cell, 1987)
- TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. (Journal of Biological Chemistry, 1991)
- Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane (Nature, 1983)
- Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. (Journal of Biological Chemistry, 1986)
- Phorbol diester receptor copurifies with protein kinase C (Proceedings of the National Academy of Sciences of the United States of America, 1983)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1C(C2(C(C2(C)C)C3C1(C4C=C(C(=O)C4(CC(=C3)CO)O)C)O)O)O
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InChIKeyQGVLYPPODPLXMB-UHFFFAOYSA-N
- Pubchem - PHORBOL
- Wikipedia - phorbol
Phorbol is a natural, plant-derived organic compound. It is a member of the tigliane family of diterpenes. Phorbol was first isolated in 1934 as the hydrolysis product of croton oil, which is derived from the seeds of the purging croton, Croton tiglium.
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