| Weight | 371.433 g/mol |
|---|---|
| Formula | C21H25NO5 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 5 |
colcemid (477-30-5)
Demecolcine · Colcemide · Colchamine
Score:
#59 in Molecular and cellular biology
,
#1822 in Biochemistry
,
#3961 in Biology
,
#4987 in Chemistry
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- Sigma-Aldrich - colcemid45.00 - 743.00 USD
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- LIFE CYCLE ANALYSIS OF MAMMALIAN CELLS. I. A METHOD FOR LOCALIZING METABOLIC EVENTS WITHIN THE LIFE CYCLE, AND ITS APPLICATION TO THE ACTION OF COLCEMIDE AND SUBLETHAL DOSES OF X-IRRADIATION. (Biophysical Journal, 1963)
- Effect of colcemid on the locomotory behaviour of fibroblasts. (Development, 1970)
- The effects of colcemid inhibition and reversal on the fine structure of the mitotic apparatus of Chinese hamster cells in vitro. (Journal of Ultrastructure Research, 1967)
- Colcemid and the mitotic cycle (Journal of Cell Science, 1992)
- Synchronization of Chinese hamster cells by reversal of Colcemid inhibition (Experimental Cell Research, 1965)
- CHO mutants resistant to colchicine, colcemid or griseofulvin have an altered -tubulin (Cell, 1980)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Demecolcine
- Colcemide
- Colchamine
- Demecolcine, (+-)-Isomer
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SMILESCNC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
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InChIKeyNNJPGOLRFBJNIW-UHFFFAOYSA-N
- Pubchem - colcemid
- Wikipedia - demecolcine
Demecolcine, also known as Colcemid, is a drug used in chemotherapy. It is closely related to the natural alkaloid colchicine with the replacement of the acetyl group on the amino moiety with methyl, but it is less toxic. It depolymerises microtubules and limits microtubule formation (inactivates spindle fibre formation), thus arresting cells in metaphase and allowing cell harvest and karyotyping to be performed.
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colcemid
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